Abstract: Objective To investigate the effectiveness of dexmedetomidine combined with remifentanil in the anesthesia for liposuction. Methods Sixty patients for liposuction were randomly divided into 3 groups （n=20）： dexmedetomidine＋ remifentanil group （group DF）, dexmedetomidine group （group D） and local anesthesia group （group N）. Group DF and group D were intravenously infused with 1 Ixg/Kg dexmedetomidine in ten minutes. Group DF received remifentanil 0.1 p,g/Kg.min in addition, When the Ramsay sedation score reached 3 points, operation started. The rate of dexmedetomidine was maintained 0.5 μg/（Kg .h） during the operation. No intravenous anesthetics was given in Group N. All groups were injected with tumescent fluid. Scoring criteria included Ramsay sedation score, VAS pain score and HR, MAP, SPO2 in different time point were all observed. And the adverse reactions were recorded. Results HR, MAP in group N were higher than in group DF and group D （P〈0.05）. No difference of HR, MAP and SPO2 were observed between group DF and group D （P〉0,05）. The VAS pain score in group DF and group D were both higher than in group N （P〈0.05）. The VAS pain score in group DF was also better than in group D （P〈0.05）. No serious adverse reactions were observed in all groups. Conclusion Dexmedetomidine combined with remifentanil used for liposuetion is effective, and is superior to single use of dexmedetomidine.

Key words: Dexmedetomidine, Remifentanil, Liposuction