Evaluation of Three Kinds of Skin Repair Materials on the Effectiveness of Skin Injury Repair in Diabetic Rats

doi:10.3969/j.issn.1673-0364.2020.03.015

Abstract

Abstract:

Objective To evaluate the effectiveness of collagen, carboxymethyl chitosan and gelatin bioactive glass in repairing the skin injury of diabetic rats.

Methods The best skin injury model of diabetic rats was established by injecting different concentration of STZ solution in single time and excising the whole skin of different sizes in the back of SD male rats respectively. Three kinds of skin dressings were attached directly to the injured area and covered with sterile dressings in order to promote skin healing. The general wound recovery was observed and wound healing rate of each group was calculated. HE staining was used to observe the recovery of wound in different periods.

Results A single intraperitoneal injection of 75 mg/Kg STZ solution and the construction of 2 cm×2 cm back skin injury could establish the best skin injury model of diabetic rats. Collagen and gelatin bioactive glass promoted skin healing to a certain extent, and the healing rate was statistically different from the blank control.

Conclusion Collagen and gelatin bioactive glass have therapeutic effect on skin injury of diabetic rats, carboxymethyl chitosan only has hemostatic effect in early stage.

Key words: Diabetes, Skin injury, Collagen, Carboxymethyl chitosan, Gelatin bioactive glass

CLC Number:

R628

Qianqian HAN, Mingyue QU, Bin XUE, Chunren WANG. Evaluation of Three Kinds of Skin Repair Materials on the Effectiveness of Skin Injury Repair in Diabetic Rats[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2020, 16(3): 232-236.

Figures/Tables 4

References 29

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