Serum level of 25-vitamin D3 in pregnant women and its correlation with gestational diabetes mellitus and predictive value for occurrence of GDM

doi:10.16150/j.1671-2870.2019.06.006

Abstract

Abstract:

Objective: To investigate the correlation between serum level of 25-vitamin D₃ [25(OH)D₃] and gestational diabetes mellitus (GDM), and to analyze whether 25(OH)D₃ can predict the occurrence of GDM. Methods: The pregnant women registered in our hospital in 2018 were tested for fast blood glucose (FBG) and glycated hemoglobin (HbA1c) in first trimester (8-12 week), serum 25(OH)D₃ in second trimester (13-15 week), and oral glucose tolerance test (OGTT) in second and third trimester (24-28 week). The pregnant women were categorized into gestational diabetes mellitus group (GDM) (1 130 cases) and normal pregnant group (control group) (1 102 cases). Compared the related indices between the two groups, analyzed the correlation between 25(OH)D₃ and each index and the predictive value of 25(OH)D₃ for GDM. Results: There were no significant differences in BMI and age between the two groups (P>0.05). The serum 25(OH)D₃ level in GDM group was lower than that in control group [(45.10±15.84) nmol/L vs (46.77±16.61) nmol/L, P<0.05]. Vitamin D level in pregnant women was generally low: 25(OH)D₃ was inadequate in 95%, and deficient in up to 60%. There was a negative correlation between 25(OH)D₃ and FBG in early pregnancy (r=-0.063, P=0.035). At the fasting time point of OGTT, there was a significant difference in level of 25(OH)D₃ [（45.61±16.74） nmol/L vs （43.73±14.12） nmol/L (P<0.05)] between the two groups having or not having normal FBG, and there was no significant difference in other time points of GOTT between the two groups. The area under ROC curve for serum 25(OH)D₃ to predict GDM was less than 0.5. Conclusions: Vitamin D level in pregnant women is generally low in Shanghai. Level of 25(OH)D₃ is negatively correlated with FBG level, however, serum 25(OH)D₃ in second trimester is not suitable for predicting GDM.

Key words: Gestation period, Diabetes, 25(OH)D₃

CLC Number:

R714.25

YAO Xiaoyan, CHEN Jun. Serum level of 25-vitamin D₃ in pregnant women and its correlation with gestational diabetes mellitus and predictive value for occurrence of GDM[J]. Journal of Diagnostics Concepts & Practice, 2019, 18(06): 634-639.

Figures/Tables 6

References 29

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组别	BMI（kg/m²）	年龄(岁)
GDM组（n=1 130）	21.5±3.7	31.0±2.5
对照组（n=1 102）	20.9±2.7	30.2±3.6

组别	FBG(mmol/L)	HbA1c(%)	25(OH)D₃(nmol/L)	OGTT(mmol/L)
组别	FBG(mmol/L)	HbA1c(%)	25(OH)D₃(nmol/L)	FBG	1 h PBG	2 h PBG
GDM组	4.74±0.39	5.23±0.38	45.10±15.84	4.82±0.62	9.86±1.43	8.45±1.43
对照组	4.42±0.29	5.04±1.13	46.77±16.61	4.39±0.26	7.08±1.34	6.07±0.98
T值	21.34	5.41	-2.423	21.685	47.41	45.11
P值	<0.001	<0.001	0.010	<0.001	<0.001	<0.001

组别	例数(n)	充足	不足	缺乏	严重缺乏
GDM组	1 130	53(4.7)	332(29.4)	662(58.6)	83（7.3）
对照组	1 102	64(5.8)	357(32.4)	620(56.3)	61（5.5）

相关分析	孕早期 FBG	孕早期 HbAlc	OGTT
相关分析	孕早期 FBG	孕早期 HbAlc	FBG	1 h PBG	2 h PBG
r值	-0.063	-0.01	-0.049	0.40	0.038
P值	0.035	0.830	0.101	0.174	0.205

时间	血糖值（mmol/L）	例数（n）	25（OH）D₃ (nmol/L)	P值
空腹	<5.1	766	45.61±16.74	0.049
	≥5.1	364	43.73±14.12
1 h	<10.0	527	44.50±15.42	0.237
	≥10.0	603	45.62±16.20
2 h	<8.5	455	44.54±15.3	0.334
	≥8.5	675	45.47±16.20

Serum level of 25-vitamin D₃ in pregnant women and its correlation with gestational diabetes mellitus and predictive value for occurrence of GDM

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