Abstract: Objective To explore the effects of surgical management for the treatment of giant neurofibroma in soft tissue.Methods From January 2004 to December 2013, 21 patients with giant neurofibromas were treated surgically. According to the location and extent of the lesion, as well as the adjacent anatomy, surgical management was performed： partially or almost completely excision with surgical flap or skin graft for repairing. Expander and preoperative interventional embolization of tumor＇s nutrient arteries were used when appropriately. Results In this study, partially（n=10） or almost completely（n=4）removal of the tumor was performed. The wounds were repaired by skin flap or skin graft. One case underwent expander treatment and 6 cases underwent preoperative interventional embolization of tumor＇s nutrient arteries, which successfully reduced the bleeding in operation. Most of the skin flap and skin graft survived well（17/21）, poor wound healing was observed in 4 cases which healed by dressing. After operation, the local appearance and the function of the limbs were improved obviously. Conclusion For the giant neurofibroma, surgical treatment effectively reduces the tumor burden,rehabilitates the appearance and function, and so improves the quality of life. Skin expandor and interventional embolization of nutrient artery can be used when appropriately.

Key words: Neurofibroma, Operation, Interventional embolization, Expander