Abstract:

　Objective　To evaluate the efficacy of a topical compound of barley protein and nicotinamide in anti-wrinkle

and facial brightening. Methods　From June to September 2020, 31 patients with a requirement for facial rejuvenation and skin

lightening were included in the study. The topical compound of barley protein and nicotinamide was applied twice a day (2 drops

in the morning and 4 drops in the evening). The changes in periocular wrinkles, skin elasticity and melanin index were evaluated

at 4-week and 8-week follow-up. Results　After 8 weeks of treatment, 21 subjects showed significant improvement in the

wrinkles around eyes, with an effective rate of 68%. VISIA showed that the number of facial wrinkles decreased significantly

after 4 and 8 weeks of application (P<0.05). The R2 value of skin elasticity was significantly higher after 4 weeks of application

(P<0.05). No treatment related side effects were observed. Conclusion　Topical application of barley protein and nicotinamide

can lighten wrinkles and brighten skin.

Key words:

　Rejuvenation, 　Skin aging, 　Safety, 　Clinical efficacy