Journal of Tissue Engineering and Reconstructive Surgery ›› 2024, Vol. 20 ›› Issue (3): 382-.

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Research progress on the mechanism of skin aging caused by ultraviolet radiation

  

  • Online:2024-06-01 Published:2024-07-05

Abstract:

Skin exposed to sunlight for a long period of time will have impaired function and even genetic material
alteration, which is manifested by aging characteristics such as water loss, elasticity loss, wrinkle growth, melanin
deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex, the ultraviolet light in
sunlight has a particularly obvious effect on skin aging, the ultraviolet light that can act on the skin is divided into two kinds:
UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging: oxidative stress, damaging
genetic material, changing the epidermal microbial community, destroying the function and structure of organelles, and
reshaping the extracellular matrix (ECM).In this paper, these five mechanisms were reviewed, and research directions and
prospects in this field were proposed.

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