Objective To explore the therapeutic effect of triamcinolone acetonide combined with pingyangmycin in the treatment of microcystic lymphatic malformations. Methods From March 2022 to March 2024，48 children with microcystic lymphangioma were divided into two groups， namely the experimental group treated with combination of triamcinolone acetonide and pingyangmycin and the control group treated with pingyangmycin alone. The cure rate after 1，2 and 3 treatments and complication rate of the two groups were compared. Results The cure rate of the experimental group after 1， 2， and 3 treatments were 32.00% 60.00%， and 92.00%， respectively， while those of the control group were 4.35%， 30.43%， and 60.87%， respectively. The cure rate of the two groups after 3 treatments was significantly higher than that after 1 treatment （P<0.001）； After each treatment， the cure rate of the experimental group was higher than that of the control group （P<0.05）. The complication rate of the experimental group （12.00%） was lower than that of the control group （39.13%）， and the difference was statistically significant （P<0.05）. Conclusion The combination of triamcinolone acetonide and pingyangmycin in the treatment of microcystic lymphatic malformations can improve the cure rate and reduce the incidence of complications， and can be a better clinical treatment option.

 , Triamcinolone acetonide, Pingyangmycin, Lymphatic malformations, Microcystic, Sclerotherapy