Journal of Tissue Engineering and Reconstructive Surgery ›› 2019, Vol. 15 ›› Issue (3): 146-151.doi: 10.3969/j.issn.1673-0364.2019.03.005

• Original article • Previous Articles     Next Articles

Weighted Genes Co-Expression Network Analysis of M2 Macrophages Regulating Hypertrophic Scar F ormation

WANG Zi,SUN Tingye,TAO Xiaoting,WANG Xin,ZHUANG Meiting,LI Haizhou,LI Qingfeng   

  1. Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China)
  • Received:2019-03-15 Revised:2019-04-20 Online:2019-06-20 Published:2019-06-20

Abstract: Objective To explore the specific mechanism of M2 macrophages and Th2 cytokines in the process of hypertrophic scar formation.Methods The weighted gene co-expression network analysis(WGCNA)was used to analysis the genome-wide expression data of mouse hypertrophic scar GSE26390,and the co-expression gene module and core regulatory genes highly correlated with M2 macrophage,Th2 cytokine and fibrosis were obtained.Results The following 8 genes were identified as core regulatory genes of M2 macrophages and Th2 type cytokines involved in the formation of hypertrophic scar:CLEC4A,CYBA,LOXL2,Hcvn1,NCKAP1L,PRRX2,LGALS9,CMTM3.Conclusion The above eight genes are involved in the regulation of immune response,extracellular matrix formation,tissue repair and other processes related to macrophage and T cells,and are potential new targets for prevention and treatment of hypertrophic scars.

Key words: Hypertrophic scar, M2 macrophages, Th2 cytokines

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