Exploratory Research for Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells on Femoral Head Osteonecrosis

doi:10.3969/j.issn.1673-0364.2009.04.006

Abstract

Abstract: Objective To explore the clinical feasibility and therapeutic effect of mesenchymal stem cells modified by hepatocyte growth factor gene for treating femoral head osteonecrosis.Methods Autologous bone marrow mesenchymal stem cells(MSCs) from one patient with osteonecrosis of the femoral head in a stage of ARCO ⅢB were separated and expanded in vivo.Cells were modified by an adenoviral vector carrying human hepatocyte growth factor gene,and total cells of 1.0×107 were surgically implanted into the necrotic s...

Key words: Femoral head necrosis, Mesenchymal stem cells, Hepatocyte growth factor

CLC Number:

R683.42

LOU Xiao,GONG Ennian,SHANG Fengyuan,WEI Chenggang,SHI Zhichao,WANG Jinsong,WU Zuze,GUO Zikuan. Exploratory Research for Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells on Femoral Head Osteonecrosis[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2009, 5(2): 83-107.

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Exploratory Research for Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells on Femoral Head Osteonecrosis

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