Abstract: Meaning construction is central to translation which is imperative for cross-cultural transmission. Based on his meaning nihilism and meaning holism, Quine points out that two factors—the indeterminacy of intensional meaning and the indeterminacy of extensional reference, are conducive to the indeterminacy of translation. Quine’s thesis is of philosophical significance. Nevertheless, both translatability and untranslatability are relative. Translation is a dynamic process of meaning construction in accordance with features of the source language and culture on the basis of the translator’s understanding of the commonalities of human culture and language.