诊断学理论与实践 ›› 2023, Vol. 22 ›› Issue (06): 550-554.doi: 10.16150/j.1671-2870.2023.06.006
收稿日期:
2023-09-06
出版日期:
2023-12-25
发布日期:
2024-03-18
通讯作者:
王慧 E-mail:cs1324@126.com基金资助:
KONG Xiaoxiao, CHEN Ping, NIU Jianmei, LÜ Mingli, WANG Hui()
Received:
2023-09-06
Published:
2023-12-25
Online:
2024-03-18
摘要:
目的: 分析自身免疫相关复发性流产(recurrent spontaneous abortion,RSA)患者的子宫动脉及子宫内膜的超声血流参数,为临床诊断提RSA供参考。方法: 连续选取2021年3月至2022年3月间48例流产2次以上的连续病例,于排卵后6~9 d经阴道三维探头检测子宫内膜厚度、子宫内膜容积、子宫内膜血流动力学指标[子宫内膜血管形成指数(vascularization index,VI)、血管形成-血流指数(vascularization flow index,VFI)]及双侧子宫动脉血流参数[子宫动脉阻力指数(resistance index,RI)、搏动指数(pulsatility index,PI)、收缩期/舒张期比值(peak systolic to lowest diastolic velocity ratio,S/D)]。检测患者自身免疫相关指标(抗核抗体、抗心磷脂抗体、β2糖蛋白Ⅰ、抗双链DNA抗体),将结果均阴性者归入非自身免疫相关RSA组(对照组),存在1项以上异常者为自身免疫相关RSA组(观察组)。比较2组间超声参数差异,并采用受试者工作特征(receiver operating characteristic,ROC)曲线评价超声参数预测自身免疫相关RSA的价值。结果: 本组自身免疫相关RSA病例数占临床RSA的25%。观察组VI、VFI值低于对照组(P=0.005、0.017),而双侧子宫动脉PI、RI值高于对照组(P≤0.001、0.001),余指标无差异。ROC曲线显示,子宫动脉PI值>2.895、RI值>0.885、子宫内膜VI值<1.518%、VFI值<0.140,预测自身免疫相关RSA的曲线下面积(AUC)分别为0.738、0.746、0.809、0.774。结论: 相对于非自身免疫相关RSA,自身免疫相关RSA患者的子宫动脉PI值、RI值增高,子宫内膜血流灌注减少;临床超声检查发现此类参数变化,应注意筛查自身免疫相关指标,以明确RSA原因。
中图分类号:
孔晓晓, 陈萍, 牛建梅, 吕明丽, 王慧. 自身免疫相关复发性流产子宫动脉及子宫内膜超声参数分析[J]. 诊断学理论与实践, 2023, 22(06): 550-554.
KONG Xiaoxiao, CHEN Ping, NIU Jianmei, LÜ Mingli, WANG Hui. Analysis of uterine blood flow parameters in immune-related recurrent spontaneous abortion[J]. Journal of Diagnostics Concepts & Practice, 2023, 22(06): 550-554.
表1
2组间年龄及各项超声指标参数
Indice | Control group (n=36, | Observation group (n=12, | P |
---|---|---|---|
Age (year) | 31.69±4.98 | 34.67±3.96 | 0.067 |
Endometrial thickness(mm) | 8.16±2.70 | 8.79±1.95 | 0.478 |
Endometrial volume(mL) | 3.92±2.18 | 4.32±1.63 | 0.518 |
Endometrial hemodynamics | |||
VI* | 9.01 | 1.43 | 0.005 |
FI | 12.14±4.28 | 9.61±2.42 | 0.069 |
VFI* | 1.176 | 0.126 | 0.017 |
Uterine artery | |||
S/D* | 6.58 | 11.28 | 0.415 |
PI | 2.33±0.44 | 3.49±1.50 | 0.000 |
RI | 0.84±0.04 | 0.90±0.07 | 0.001 |
表2
超声参数预测自身免疫相关RSA的ROC曲线分析
Indice | AUC | 95%CI of AUC | SE | P | cut off value | Sensitivity | Specificity | Youden index |
---|---|---|---|---|---|---|---|---|
VI | 0.809 | 0.629-0.890 | 0.085 | 0.001 | 1.518% | 63.64% | 91.67% | 0.553 |
VFI | 0.774 | 0.599-0.870 | 0.102 | 0.013 | 0.140 | 63.64% | 91.67% | 0.553 |
PI | 0.738 | 0.574-0.852 | 0.111 | 0.015 | 2.895 | 58.33% | 93.94% | 0.523 |
RI | 0.746 | 0.579-0.856 | 0.098 | 0.028 | 0.885 | 50.00% | 93.94% | 0.440 |
PI+VFI combination | 0.679 | 0.517-0.814 | 0.103 | 0.029 | — | 75.00% | 78.79% | 0.538 |
[1] |
QUENBY S, GALLOS I D, DHILLON-SMITH R K, et al. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss[J]. Lancet, 2021, 397(10285):1658-1667.
doi: 10.1016/S0140-6736(21)00682-6 pmid: 33915094 |
[2] |
SHI Y, TAN D, HAO B, et al. Efficacy of intravenous immunoglobulin in the treatment of recurrent spontaneous abortion: A systematic review and meta-analysis[J]. Am J Reprod Immunol, 2022, 88(5):e13615.
doi: 10.1111/aji.v88.5 URL |
[3] | 高戈, 张云山. 影响胚胎种植率关键因素的研究进展[J]. 国际生殖健康/计划生育杂志, 2019, 38(2):154-157. |
GAO G, ZHANG Y S. Main Factors Related to the Rate of Embryo Implantation[J]. J Int Reprod Health/Fam Plann, 2019, 38(2):154-157. | |
[4] | 余彩茶, 水旭娟, 焦岩, 等. 子宫动脉及内膜血流在评估子宫内膜容受性及预测妊娠结局中的应用价值[J]. 医学研究杂志, 2022, 51(3):75-79. |
YU C C, SHUI X J, JIAO Y, et al. Application value of uterine artery and endometrial blood flow in evaluating endometrial receptivity and predicting pregnancy Outcome[J]. J Med Res, 2022, 51(3):75-79. | |
[5] | 国家妇幼健康研究会生殖免疫学专业委员会专家共识编写组. 复发性流产抗血栓药物治疗中国专家共识[J]. 中华生殖与避孕杂志, 2022, 42(12):1207-1217. |
Expert consensus writing group of Reproductive Immunology Professional Committee of National Maternal and Child Health Research Association. Antithrombotic drug use for recurrent spontaneous abortion: a Chinese expert consensus[J]. Chin J Reprod Contracept, 2022, 42(12):1207-1217. | |
[6] | 秦诗, 高玉平. 复发性流产的免疫学因素研究进展[J]. 中华生殖与避孕杂志, 2018, 38(2):165-169. |
QIN S, GAO Y P. Process in immune etiology of recurrent spontaneous abortion[J]. Chin J Reprod Contracept, 2018, 38(2):165-169. | |
[7] |
CHRISTIANSEN O B, STEFFENSEN R, NIELSEN H S, et al. Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications[J]. Gynecol Obstet Invest, 2008, 66(4):257-267.
doi: 10.1159/000149575 pmid: 18679035 |
[8] |
MOR G, CARDENAS I, ABRAHAMS V, et al. Inflammation and pregnancy: the role of the immune system at the implantation site[J]. Ann N Y Acad Sci, 2011, 1221(1):80-87.
doi: 10.1111/nyas.2011.1221.issue-1 URL |
[9] |
MOR G, ALDO P, ALVERO A B. The unique immunological and microbial aspects of pregnancy[J]. Nat Rev Immunol, 2017, 17(8):469-482.
doi: 10.1038/nri.2017.64 pmid: 28627518 |
[10] |
HABETS D H J, PELZNER K, WIETEN L, et al. Intravenous immunoglobulins improve live birth rate among women with underlying immune conditions and recurrent pregnancy loss: a systematic review and meta-analysis[J]. Allergy Asthma Clin Immunol, 2022, 18(1):23.
doi: 10.1186/s13223-022-00660-8 pmid: 35277202 |
[11] |
RIDDER A, GIORGIONE V, KHALIL A, et al. Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function[J]. Int J Mol Sci, 2019, 20(13):3263.
doi: 10.3390/ijms20133263 URL |
[12] | LLOYD-DAVIES C, COLLINS S L, BURTON G J. Understanding the uterine artery Doppler waveform and its relationship to spiral artery remodelling[J]. Placenta, 2021,105:78-84. |
[13] | BAZER F W, SPENCER T E, JOHNSON G A, et al. Ute-rine receptivity to implantation of blastocysts in mammals[J]. Front Biosci (Schol Ed), 2011, 3(2):745-767. |
[14] | TEKTONIDOU M G. Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and athe-rothrombosis[J]. J Autoimmun, 2022, 128:102813. |
[15] | 张译爻, 王玉贤, 崔向荣. 复发性流产与遗传性易栓症的研究进展[J]. 中国临床研究, 2022, 35(10):1449-1453. |
ZHANG Y Y, WANG Y X, CUI X R. Research progress of recurrent abortion and hereditary thrombophilia[J]. Chin J Clin Res, 2022, 35(10):1449-1453. | |
[16] | 王世帅, 叶利群, 单丽华, 等. 加味寿胎丸治疗多囊卵巢综合征合并复发性流产临床效果及对血栓前状态的影响[J]. 中华全科医学, 2023, 21(8): 1339-1342. |
WANG SS, YE LQ, SHAN LH, et al. Clinical efficacy of Jiawei Shoutai Pills in the treatment of polycystic ovary syndrome with recurrent miscarriage and its impact on pre thrombotic state[J]. Chin J General Prac, 2023, 21(8): 1339-1342. | |
[17] | ARREOLA-DIAZ R, MAJLUF-CRUZ A, SANCHEZ-TORRES L E, et al. The pathophysiology of the antiphospholipid syndrome: a perspective from the blood coagulation system[J]. Clin Appl Thromb Hemost, 2022, 28:10760296221088576. |
[18] | 苏倩, 凌琳, 虞红珍, 等. 复发性流产患者微小RNA155与子宫内膜HIF-1α VEGF 微血管密度的关系[J]. 安徽医学, 2022, 43(3):314-317. |
SU Q, LING L, YU H Z, et al. The relationship between VEGF microvascular density and micro RNA155 and endometrial HIF-1 in patients with recurrent miscarriage[J]. Anhui Med J, 2022, 43(3):314-317. | |
[19] |
ALBRECHT E D, PEPE G J. Regulation of uterine spiral artery remodeling: a review[J]. Reprod Sci, 2020, 27(10):1932-1942.
doi: 10.1007/s43032-020-00212-8 pmid: 32548805 |
[1] | 曹云云, 龚晓萍, 王海飞, 王冠杰, 曾敏. 妊娠11~40周子宫动脉平均搏动指数参考值范围的建立及验证[J]. 诊断学理论与实践, 2023, 22(04): 374-378. |
[2] | 胡静静, 沈银忠, 刘莉, 卢洪洲. 艾滋病合并播散性非结核分枝杆菌病诊治现状及研究进展[J]. 诊断学理论与实践, 2023, 22(04): 402-406. |
[3] | 乌心怡, 潘萌, 朱海琴. 自身免疫性大疱性皮肤病的实验室诊断进展[J]. 诊断学理论与实践, 2023, 22(03): 306-310. |
[4] | 谢雅琼, 林孝怡. 血清游离轻链在鉴别诊断不同病因肾病的应用价值及其与患者肾功能分期的相关性分析[J]. 诊断学理论与实践, 2023, 22(02): 166-171. |
[5] | 许建昆, 周露婷, 张文净, 许海敏, 王朝夫. CA9在透明细胞肾细胞癌预后评估中的价值[J]. 诊断学理论与实践, 2023, 22(01): 37-43. |
[6] | 陈晟, 张仪纵横. 从抗IgLON5病看神经免疫与神经变性间的联系[J]. 诊断学理论与实践, 2022, 21(06): 663-668. |
[7] | 张天羽, 周东, 洪桢. 《儿童抗NMDAR脑炎治疗的国际共识推荐》解读[J]. 诊断学理论与实践, 2022, 21(06): 677-683. |
[8] | 闫化茹, 刘坤, 韩志宏, 房振, 吴丽莉. 肾上腺旁吻合状血管瘤1例并文献复习[J]. 诊断学理论与实践, 2022, 21(06): 735-740. |
[9] | 张美玲, 朱潇邦, 宋爱玲, 周剑平, 李庆云. 小细胞肺癌患者采用PD-L1抑制剂治疗致垂体炎1例报道并文献复习[J]. 诊断学理论与实践, 2022, 21(06): 741-745. |
[10] | 陈志敏, 何浩岚. 艾滋病合并马尔尼菲篮状菌病的诊治现状[J]. 诊断学理论与实践, 2022, 21(04): 425-430. |
[11] | 赵含丹, 许利军. 人类免疫缺陷病毒相关隐球菌脑膜炎的诊治现状和挑战[J]. 诊断学理论与实践, 2022, 21(04): 419-424. |
[12] | 陈志敏, 刘波, 何浩岚, 何耀祖, 冯理智, 刘新华, 张坚生, 蔡卫平, 李凌华. 133例艾滋病合并马尔尼菲篮状菌病死亡病例分析[J]. 诊断学理论与实践, 2022, 21(04): 444-449. |
[13] | 胡静静, 吕海伟, 荀静娜, 沈银忠, 刘莉, 卢洪洲. 2012年至2021年上海市艾滋病合并分枝杆菌感染患者的菌种分布特征[J]. 诊断学理论与实践, 2022, 21(04): 450-455. |
[14] | 陈宏, 沈银忠. 人类免疫缺陷病毒感染/艾滋病合并结核病的诊治进展[J]. 诊断学理论与实践, 2022, 21(04): 530-534. |
[15] | 刘萍, 肖园, 王歆琼, 陆亭伟, 赵雪松, 杨媛艳. Wiskott-Aldrich综合征合并克罗恩病一例并文献复习[J]. 诊断学理论与实践, 2022, 21(03): 349-354. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||