阿尔茨海默病的临床诊治进展

doi:10.16150/j.1671-2870.2022.01.005

摘要/Abstract

中图分类号:

R749.1⁺6

李建平, 任汝静, 王刚. 阿尔茨海默病的临床诊治进展[J]. 诊断学理论与实践, 2022, 21(01): 18-21.

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参考文献 29

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药物	研发公司	研究人群	结合Aβ类型	表位	抗体来源	IgG亚类	研究状态
Aducanumab	渤健	AD源性MCI和轻度AD	Aβ聚集体（不溶性纤维和可溶性寡聚物）	N端	全人序列	IgG₁	获美国FDA上市批准
Donanemab	礼来	轻度AD	Aβ斑块	Aβ（p3-42）	人鼠杂交序列	IgG₁	Ⅲ期研究进行中获美国FDA突破性疗法认定
Lecanemab （BAN2401）	渤健/卫材	淀粉样蛋白生物标志物阳性的轻度AD	可溶性Aβ聚集体	N端	人鼠杂交序列	IgG₁	Ⅲ期研究进行中获美国FDA快速通道资格
Gantanerumab	罗氏	轻中度AD	纤维型Aβ	N端和中间区域	全人序列	IgG₁	Ⅲ期研究进行中获美国FDA突破性疗法认定

阿尔茨海默病的临床诊治进展

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