Epidemiological analysis of human papilloma virus infection in male patients with condyloma acuminatum during 2017-2018 in Shanghai

doi:10.16150/j.1671-2870.2020.06.005

Abstract

Abstract:

Objective: To investigate the epidemiological characteristics of human papilloma virus (HPV) infection in male patients with condyloma acuminatum in Shanghai, and to provide evidence for prevention and treatment of the disease. Methods: A total of 2 202 male patients with condyloma acuminatum diagnosed in the dermatology clinic of our hospital were enrolled between March 2017 and March 2018, and HPV infection status was explored. The HPV genotypes in skin lesion were tested with polymerase chain reaction (PCR)-reverse dot blot hybridization. Results: It showed 1 136 out of 2 202 patients were HPV DNA positive and positive rate was 51.59%. The positive rates of low-risk HPV 6 and 11 were 42.78% and 27.02%, while the high-risk HPV 16, 52 and 51 were 12.06%, 10.83% and 7.22% respectively. In 1 136 cases with positive HPV DNA, single infection was the main pattern with a positive rate of 56.78%. In patients with multiple HPV infection, double infection was the main form, accounting for 25.62%. It showed that 44.45% patients were infected with low-risk genotypes of HPV (single,double or triple HPV genotype infection), 34.07% patients had mixed infection of high-risk and low risk genotypes ( up to ten infections); 21.48% were only high-risk HPV infection (up to six infections). The positive detection rate in 41-60 year group was the highest (60.35%), which was significantly higher than the groups of ≤20 year and 21-40 year (all P<0.05, χ²=4.09 and χ²=13.57). Infection patterns among different age groups were as follows: 21-40 year patients were mainly infected by one single genotype,and majority patients in both≤20 year and ≥61 year group had multiple HPV infection. Conclusions: The detection rate of positive HPV DNA in male patient with condyloma acuminatum in Shanghai is 51.59%, and lower than the rates reported in Henan, Zhejiang and Dongguan(Guangdong), and the genotypes include HPV 6,11,16,52,51.The infection was mainly caused by single and low-risk HPV. Detection rate in 41-60 year male is the highest, and the proportion of multiple infections are higher in people ≤20 years and ≥61 years.

Key words: Male, Condyloma acuminatum, Human papilloma virus, Genotype, Epidemiology

CLC Number:

R511

WANG Juan, LI Jia. Epidemiological analysis of human papilloma virus infection in male patients with condyloma acuminatum during 2017-2018 in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2020, 19(06): 572-576.

Figures/Tables 3

References 16

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HPV感染模式	HPV感染重数
HPV感染模式	单一感染	二重感染	三重感染	四重感染	五重感染	六重感染	七重感染	八重感染及以上	合计
单纯低危型	456 (40.14)	45 (3.96)	4 (0.35)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	505（44.45）
单纯高危型	189 (16.64)	42 (3.70)	8 (0.70)	4 (0.35)	0 (0)	1 (0.09)	0 (0)	0 (0)	244 (21.48)
高低危混合型	0 (0)	204 (17.96)	96 (8.45)	42 (3.70)	21 (1.85)	10 (0.88)	9 (0.79)	5 (0.44)	387 (34.07)
合计	645 (56.78)	291 (25.62)	108 (9.50)	46 (4.05)	21 (1.85)	11 (0.97)	9 (0.79)	5 (0.44)	1 136 (100.00)

年龄分组（岁）	例数(n)	阳性(n)	组内阳性检出率（%）	占总人数比例（%）	单一感染 [n(%)]	多重感染 [n（%）]	单纯低危型 [n（%）]	单纯高危型 [n（%）]	高低危混合型 [n（%）]
≤20	100	49	49.00	2.23	22（44.90）	27（55.10）	17（34.69）	8（16.33）	24（48.98）
21~40	1 657	819	49.43	37.19	489（59.71）	330（40.29）	380（46.40）	178（21.73）	261（31.87）
41~60	343	207	60.35	9.40	109（52.66）	98（47.34）	86（41.55）	46（22.22）	75（36.23）
≥61	102	61	59.80	2.77	25（40.98）	36（59.02）	22（36.07）	12（19.67）	27（44.26）
合计	2 202	1 136	51.59	51.59	645（56.78）	491（43.22）	505（44.45）	244（21.48）	387（34.07）