Abstract: Objective: To investigate the correlation between C1q tumor necrosis factor-related protein 1（CTRP1) and coronary atherosclerotic heart disease（CHD）. Methods: A total of 203 patients with suspected CHD were divided into two groups based on the results of coronary angiography: CHD group(n=103) and control group(n=100). The serum levels of CTRP1, adiponectin（APN）, tumor necrosis factor-α（TNF-α）, IL-6, IL-8, intracellular adhesion molecule 1（ICAM-1）, vascular cell adhesion molecule-1（VCAM-1）and monocyte chemotactic protein-1（MCP-1）were detected by ELISA. SPSS19.0 statistical software was used to analyze the data obtained. Results: The serum level of CTRP1 in CHD group was significantly higher than those in control group [(16.68±; 12.10) ng/mL vs (10.27±; 5.68) ng/mL, P< 0.001 ). After adjusted for gender, age, fasting plasma glucose (FPG) and HbA1c, CTRP1 level in CHD group was correlated with Gensini score（r=0.279, P=0.015）. Based on the quartile of Gensini score, CTRP1 level in the top quartile group was significantly higher than the other three groups [(23.45±; 18.87） ng/mL vs（11.27±; 5.88） ng/mL, （15.15±; 9.12） ng/mL, （17.00±; 7.82） ng/mL, all P< 0.05)]. After adjusted for gender, age, FPG and HbA1c, correlation analysis revealed that CTRP1 was positively correlated with TNF-α, IL-6, ICAM-1, MCP-1（r=0.260, 0.448, 0.362, 0.287, all P< 0.05）. Logistic regression analysis indicated that FPG（OR: 1.740, 95% CI: 1.027-2.880, P< 0.05）, HbA1c（OR: 2.714, 95% CI: 1.133-6.499, P< 0.05）, IL-8（OR: 1.041, 95% CI: 1.008-1.073, P< 0.05）, CTRP1（OR: 1.136, 95% CI:1.060-1.218, P< 0.05） were the risk factors for CHD. Conclusions: Serum CTRP1 level are significantly increased in patients with CHD and are positively correlated with the severity of coronary artery lesion, which suggested that CTRP1 might be used as an efficient indicator for evaluating the severity of CHD.

Key words: C1q tumor necrosis factor-related protein 1, Coronary atherosclerotic heart disease, Gensini score