Epidemiological features of major subtypes of leukemia and its incidence trends in Shanghai

doi:10.16150/j.1671-2870.2017.05.007

Abstract

Abstract: Objective: To describe the patterns of leukemia incidence in Shanghai during 2008-2012 and investigate the trends of leukemia incidence in Shanghai urban area during 1973-2012 in order to provide references for designing prevention programs, research spots and control strategies on leukemia. Methods: Data of leukemia cases were collected by the Shanghai Cancer Registry. The patterns of leukemia incidence according to gender, age, and subtypes during 2008-2012 were described. Joinpoint software was used to analyze the incidence trends, and the annual percentage changes (APCs) for the whole period and time segments were estimated. The world standard population 1960 was used for calcula-ting the age-standardized incidence(ASR). Results: During 2008-2012, 4 404 new leukemia cases were diagnosed in Shanghai, accounted for 1.53% of the total cancer cases. The crude rate of leukemia was 6.78 per 100 000 for male and 5.75 per 100 000 for female, and the ASRs were 5.14 per 100 000 and 4.11 per 100 000, respectively. ASR for total leukemia in male were higher than that in female（X=3.16, P<0.01）. Acute myeloid leukemia (AML) was the major subtype of leukemia, accounted for 18.30% of the total cases, then were the acute lymphoblastic leukemia (ALL), chronic myelocy-tic leukemia (CML) and chronic lymphocytic leukemia (CML). Differed from other subtypes, acute lymphoblastic leukemia (ALL) usually occurred among young population, with the highest incidence in 0-5 age group. The incidence of other types of leukemia increased with the increase in age. During the period of 1973-2012, leukemia incidence among males was stable, while the incidence significantly decreased among females with an APC-0.39%. Incidence of ALL increased signi-ficantly among males(APC 1.12%) and remained stable among females. Incidence of CLL increased significantly in both sex, and incidence of AML decreased significantly in females. Conclusions: The incidence of leukemia in Shanghai during 2008-2012 is similar to the average level in the world, and incidence in male is higher than that in female. AML is the major subtype of leukemia. The incidence trends varies with different subtypes. During 1973-2012, incidence of leukemia in male is stable, while decreases significantly in female. The trends differ between different subtypes.

Key words: Leukemia, Subgroup, Incidence, Trend, Epidemiology, Cancer registry, Shanghai

CLC Number:

R733.7

BAO Pingping, WU Chunxiao, ZHANG Minlu, GU Kai, XIANG Yongmei, PENG Peng, GONG Yangming, SHI Liang, ZOU Zhen.. Epidemiological features of major subtypes of leukemia and its incidence trends in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2017, 16(05): 484-491.

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