Abstract: Objective: To investigate the changes in mineral levels in middle aged and elderly patients with diabetes mellitus in Shanghai. Methods: A total of 1 100 middle aged and elderly subjects undergone health examination during January 2016 to November 2016 were enrolled. Of these subjects, 264 were diabetes and 836 were non-diabetes. All the subjects were tested for minerals(calcium, magnesium) and glycosylated hemoglobin(HbA1c), and the mineral levels between diabetic and non-diabetic groups were compared. According to the level of glycosylated hemoglobin(HbA1c) <7.0 or ≥7.0, subjects with type 2 diabetes mellitus were further divided into 2 groups: well-controlled group and poor-controlled group. The correlations of HbA1c with mineral levels were examined. Results: Compared with non-diabetes, diabetic patients had a higher serum calcium level and lower magnesium level (P<0.01 or P<0.05). Patients with HbA1c ≥7 had higher level of calcium and lower level of magnesium than patients with HbA1c<7.0 (P<0.01 or P<0.05). Linear correlation analysis showed that level of HbA1c was positively correlated with serum calcium level (r=0.074, P=0.015) and negatively correlated with serum magnesium level(r=-0.120, P<0.01). Conclusions: Compared with non-diabetes, patients with diabetes have lower level of serum magnesium and higher level of serum calcium. Poor-controlled diabetic patients have lower level of serum magnesium and higher level of serum calcium than well-controlled diabetic patients. Glycosylated hemoglobin is positively correlated with serum calcium while negatively correlated with serum magnesium.

Key words: Diabetes mellitus, Mineral, Glycosylated hemoglobin