Abstract: Objective: To investigate the clinical and pathological features of Kimura's disease (KD) for improving its diagnosis and treatment experiences. Methods: The clinical data and histological morphology of 13 cases of Kimura disease were retrospectively analyzed, with review of literature.Clinicopathological features, diagnosis and treatment of Kimura disease were summarized. Results: All the patients were male, with mean age of (41±4) years and average duration of (35±11) months. The clinical manifestations of KD were progressive and painless tumors in different sites, including 3 cases with trunk and/or limbs scattered with papules with itching, 4 cases with single tumor nodule, 9 cases with multiple tumors. The largest tumor had a diameter reaching 10.0 cm. Blood examination showed increased peripheral blood eosinophils in all the cases. Four cases had immunoglobulin IgE test performed, and it showed increased level of serum IgE. And 2 cases had bone marrow puncture performed, which revealed active proliferation of bone marrow and evident infiltration of eosinophils. Histopathologically, they mainly composed of hyperplastic lymphoid tissue, expansion of germinal center, obvious mantle zone, lymphoid follicle formation and fibrous tissue hyperplasia;small vascular hyperplasia can be seen between lymph follicles. Marked infiltration and accumulation of mature eosinophils were seen in interstitial tissue, and eosinophilic tiny abscesses were formed.Seven cases received surgical resection only, and the other 6 cases received treatment such as hormones or radiation in addition. Seven patients were followed up for 4-96 months and 5 had relapse. Conclusions: Kimura disease is a kind of benign lymphoproliferative lesion, and it is important to master its clinical features and histological morphology for improving its diagnosis.

Key words: Kimura disease, Clinical features, Pathology, Diagnosis