Journal of Diagnostics Concepts & Practice ›› 2023, Vol. 22 ›› Issue (04): 389-392.doi: 10.16150/j.1671-2870.2023.03.010
• Case reports • Previous Articles Next Articles
ZHANG Lanlan, YANG Qiao, NIE Zunzhen, GUO Ying()
Received:
2023-01-03
Online:
2023-08-25
Published:
2023-12-18
CLC Number:
ZHANG Lanlan, YANG Qiao, NIE Zunzhen, GUO Ying. Thoracic SMARCA4-deficient undifferentiated tumour: a case report[J]. Journal of Diagnostics Concepts & Practice, 2023, 22(04): 389-392.
Figure 2
Thoracic SMARCA4-deficient undifferentiated tumour A: Tumor cells showed a nest-like or diffuse solid sheet-like arrangement with extensive hemorrhage and necrosis (HE ×4); B: Some areas have a significant fibrotic stroma, which is rich in blood vessels (HE ×4); C、D: Tumor cells are arranged in a nest-mass pattern,the cytoplasm is rich,it was Epithelial-like,Plasma cell-like, Synthetic cell-like, With large vesicular nuclei and centrally located and distinct nucleoli,Partial nuclear bias,Nuclear division is easy to see (HE,C ×10, D ×20).
Figure 3
Immunocytochemical staining of the tumor tissue (Envision method) A: Tumor cells lack SMARCA4 expression,Note the positive interstitial vascular endothelial cells (×10); B: Tumor cells with INI-1 showed (×10); C: Tumor cells with ki-67 showed a high proliferation index,About 80% or more (×10); D: AE1/AE3 expression was negative in tumor cells (×4).
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