Journal of Diagnostics Concepts & Practice >

2019 , Vol. 18 >Issue 2: 133 - 138

DOI: https://doi.org/10.16150/j.1671-2870.2019.02.003

Original articles

Analysis of risk factors and prognosis of cerebral hemorrhage patients accompanied by cortical superficial siderosis

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  • 1. Department of Neurology & Institute of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
    2. Department of Neurology, The First Hospital of Jiaxing, Zhejiang Jiaxing 314000, China

Received date: 2019-02-20

  Online published: 2019-04-25

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Abstract

Objective: To investigate the related factors of cortical superficial siderosis (cSS) in cerebral hemorrhage patients associated with cerebral amylodid angiopathy (CAA) and its prognosis. Methods: A prospective study was performed on patients diagnosed as cerebral hemorrhage by CT within 3 days after onset and MRI was performed within 5 days for detecting cortical superficial siderosis (cSS ), cerebral microbleeds (CMBs) and leukoaraiosis (LA). Patients were followed up 1 year for observation of subsequent clinical cerebrovascular events. Result: Altogether 241 patients with cerebral hemorrhage were enrolled, including 185 cases of deep hemorrhage and 56 cases of lobar hemorrhage. The occurrence of cSS in lobar hemorrhage was more than that in deep hemorrhage (13/56, 23.2% vs 12/185, 6.5%, P<0.001). According to the modified Boston criteria, 42 patients (17.4%) were possible CAA. During the 1-year follow-up, 35 (14.5%) patients had clinical cerebrovascular events or death, and 13(31.0%) possible CAA patients had recurrent cerebral hemorrhage. Kaplan-Meier showed a higher risk of recurrent cerebral hemorrhage in possible CAA accompanied by cSS ( χ2=7.466, P=0.006). The multivariate COX regression model found that cSS was an independent predictor of recurrent cerebral hemorrhage in patients with possible CAA (HR 4.45; 95% CI 1.3714.48, P=0.013). Conclusions: The prevalence of cSS in patients with lobar hemorrhage was higher than that in deep bleeding. Possible CAA accompanied by cSS had an increased risk of recurrent cerebral hemorrhage within one year.

Key words： Cortical superficial siderosis; Cerebral amylodid angiopathy; Cerebral small vessel diseases; Magnetic resonance imaging

Cite this article

CHEN Jie, HU Jin, YANG Kang, FU Yi . Analysis of risk factors and prognosis of cerebral hemorrhage patients accompanied by cortical superficial siderosis[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(2) : 133 -138 . DOI: 10.16150/j.1671-2870.2019.02.003

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