Journal of Diagnostics Concepts & Practice >

2019 , Vol. 18 >Issue 06: 634 - 639

DOI: https://doi.org/10.16150/j.1671-2870.2019.06.006

Original articles

Serum level of 25-vitamin D3 in pregnant women and its correlation with gestational diabetes mellitus and predictive value for occurrence of GDM

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  • Department of Clinical Laboratory, Shanghai First Maternal and Infant Health Hospital, Tongji University School of Medicine, Shanghai 201204, China

Received date: 2019-02-28

  Online published: 2019-12-25

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Abstract

Objective: To investigate the correlation between serum level of 25-vitamin D3 [25(OH)D3] and gestational diabetes mellitus (GDM), and to analyze whether 25(OH)D3 can predict the occurrence of GDM. Methods: The pregnant women registered in our hospital in 2018 were tested for fast blood glucose (FBG) and glycated hemoglobin (HbA1c) in first trimester (8-12 week), serum 25(OH)D3 in second trimester (13-15 week), and oral glucose tolerance test (OGTT) in second and third trimester (24-28 week). The pregnant women were categorized into gestational diabetes mellitus group (GDM) (1 130 cases) and normal pregnant group (control group) (1 102 cases). Compared the related indices between the two groups, analyzed the correlation between 25(OH)D3 and each index and the predictive value of 25(OH)D3 for GDM. Results: There were no significant differences in BMI and age between the two groups (P>0.05). The serum 25(OH)D3 level in GDM group was lower than that in control group [(45.10±15.84) nmol/L vs (46.77±16.61) nmol/L, P<0.05]. Vitamin D level in pregnant women was generally low: 25(OH)D3 was inadequate in 95%, and deficient in up to 60%. There was a negative correlation between 25(OH)D3 and FBG in early pregnancy (r=-0.063, P=0.035). At the fasting time point of OGTT, there was a significant difference in level of 25(OH)D3 [（45.61±16.74） nmol/L vs （43.73±14.12） nmol/L (P<0.05)] between the two groups having or not having normal FBG, and there was no significant difference in other time points of GOTT between the two groups. The area under ROC curve for serum 25(OH)D3 to predict GDM was less than 0.5. Conclusions: Vitamin D level in pregnant women is generally low in Shanghai. Level of 25(OH)D3 is negatively correlated with FBG level, however, serum 25(OH)D3 in second trimester is not suitable for predicting GDM.

Key words： Gestation period; Diabetes; 25(OH)D3

Cite this article

YAO Xiaoyan, CHEN Jun . Serum level of 25-vitamin D3 in pregnant women and its correlation with gestational diabetes mellitus and predictive value for occurrence of GDM[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(06) : 634 -639 . DOI: 10.16150/j.1671-2870.2019.06.006

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