Investigation of serum uric acid level in adult patients and analysis of related influencing factors

doi:10.16138/j.1673-6087.2023.03.002

Abstract

Abstract:

Objective To investigate the distribution characteristics of hyperuricemia(HUA) and related influencing factors among the adult patients in Ruijin Hospital, and provide the clinical reference for prevention and treatment of HUA. Methods A retrospective study of serum uric acid was carried out on 47 100 people in Ruijin Hospital in June 2018, who were over 18 years old. Among them, 27 091 were males and 20 009 were females. The value of serum uric acid and distribution in different gender, age groups and clinical departments were studied. Results The total detection rate of HUA was 20.26%; it was 22.82% in male, and it was 16.88% in females. The serum uric acid level was negatively correlated with age in males, and females (≤50 years) (P<0.05), while it was positively correlated with female over 50 years (P<0.05). The high incidence age groups were 18-30 years in male, and in women over 71 years(P<0.05). Three departments with the highest HUA detection rate were the departments of nephrology, cardiac surgery outpatient and hypertension outpatient. Conclusions The detection rate of HUA in the study was high. The overall blood uric acid level in men was higher than that in women. The blood uric acid level in men gradually decreased with age, and the blood uric acid level in women showed a trend of decreasing and then increasing. Learning the distribution characteristics of uric acid in population could give help in strengthening education and prevention work in the susceptible population.

Key words: Chronic kidney disease, Uric acid detection, Hyperuricemia

CLC Number:

R692

LUO Yadan, YUAN Liying, LU Yide, WANG Ziqiu, WANG Zhaohui. Investigation of serum uric acid level in adult patients and analysis of related influencing factors[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(03): 141-145.

Figures/Tables 5

References 18

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组别	男性	女性	χ²	P
18~30岁	29.21（772/2 643）	13.95（310/2 223）	162.695	<0.001
31~40岁	28.47（1 158/4 067）	13.99（390/3 003）	242.250	<0.001
41~50岁	26.29（981/3 732）	10.88（338/3 107）	258.557	<0.001
51~60岁	19.94（1 088/5 457）	15.48（622/4 017）	31.025	<0.001
61~70岁	19.22（1 267/6 593）	19.56（935/4 780）	0.209	0.647
71岁以上	19.57（900/4 599）	27.20（783/2 879）	59.063	<0.001
合计	22.76（6 166/27 091）	16.88（3 378/20 009）	246.099	<0.001

组别	总体水平	男性		女性
组别	总体水平	n	血尿酸	n	血尿酸
18~30岁	334.21±103.40	2 643	376.98±93.69	2 223	283.36±90.60
31~40岁	331.62±105.67	4 067	375.38±100.79	3 003	272.36±80.18^1）
41~50岁	320.27±103.63^1）2）	3 732	363.49±99.76^1）2）	3 107	268.35±82.14^1）
51~60岁	313.86±111.56^1）2）3）	5 457	336.45±119.01^1）2）3）	4 017	283.17±92.07^2）3）
61~70岁	315.51±110.33^1）2）3）	6 593	336.04±113.92^1）2）3）	4 780	287.18±98.41^2）3）4）
71岁以上	322.61±119.99^{1）2）4）5）}	4 599	329.92±120.53^{1）2）3）4）5）}	2 879	310.94±118.21^{1）2）3）4）5）}

血尿酸分级（μmol/L）	n	男性	女性	χ²	P
0~179	3 811	1 794（6.62）	2 017（10.08）	185.092 9	<.0001
180~300	17 075	6 627（24.46）	10 448（52.22）	3 836.140 8	<.0001
301~359	10 483	6 356（23.46）	4 127（20.63）	53.493 3	<.0001
360~419	8 006	6 064（22.38）	1 942（9.71）	1 311.172 4	<.0001
420~479	4 380	3 549（13.10）	831（4.15）	1 092.286 2	<.0001
480~539	1 948	1 607（5.93）	341（1.70）	518.798 3	<.0001
540以上	1 397	1 094（4.04）	303（1.51）	254.731 3	<.0001
合计	47 100	27 091（100.00）	20 009（100.00）	/	/

部门	n	血尿酸阳性 [n（%）]	HUA阳性者血尿酸水平（μmol/L ）
肾脏病区	401	184（45.89）	498.02±109.76
门诊心外科	82	37（45.12）	477.57±66.52
门诊高血压	809	290（35.85）	461.22±62.52
门急诊泌外科	990	340（34.34）	468.53±79.63
产休病区	132	44（33.33）	505.02±131.54
门诊肾脏内科	3 432	1 129（32.90）	465.95±70.53
门诊肝移植	37	12（32.43）	492.54±82.15
预防保健科	111	34（30.63）	485.54±85.78
高血压病区	113	33（29.20）	488.53±81.87
门诊核医学	100	29（29.00）	464.93±79.49