Journal of Internal Medicine Concepts & Practice ›› 2023, Vol. 18 ›› Issue (04): 278-283.doi: 10.16138/j.1673-6087.2023.04.013
• Original article • Previous Articles Next Articles
LIN Weizhi1,2, FU Yang2, LUO Qi2, CHEN Jie2, MA Jianfang2()
Received:
2021-05-18
Online:
2023-08-30
Published:
2024-01-09
CLC Number:
LIN Weizhi, FU Yang, LUO Qi, CHEN Jie, MA Jianfang. Relationship between serum uric acid and cognitive impairment[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(04): 278-283.
项目 | 总样本(n=312) | Q1(n=80) | Q2(n=76) | Q3(n=78) | Q4(n=78) | F/χ2 | P |
---|---|---|---|---|---|---|---|
年龄(岁) | 68.36±6.45 | 68.23±6.56 | 67.84±5.46 | 68.97±7.29 | 68.40±6.42 | 0.409 | 0.747 |
男性[n(%)] | 124(39.7) | 32(40.0) | 30(39.5) | 31(39.7) | 31(39.7) | 0.005 | 1.000 |
文化程度[n(%)] | |||||||
文盲 | 91(29.2) | 25(31.3) | 19(25.0) | 26(33.3) | 21(26.9) | 2.170 | 0.903 |
小学毕业 | 124(39.7) | 32(40.0) | 32(42.1) | 27(34.6) | 33(42.3) | ||
初中毕业及以上 | 97(31.1) | 23(28.7) | 25(32.9) | 25(32.1) | 24(30.8) | ||
BMI(kg/m2) | 23.58±3.35 | 22.05±2.62 | 24.15±3.88 | 24.19±3.17 | 24.01±3.19 | 8.133 | 0.001 |
睡眠时间(h) | 6.67±1.59 | 6.49±1.44 | 6.57±1.76 | 6.95±1.49 | 6.68±1.63 | 1.228 | 0.300 |
是否打鼾[n(%)] | 128(44.8) | 27(38.0) | 29(41.4) | 36(49.3) | 36(50.0) | 3.028 | 0.387 |
运动情况[n(%)] | |||||||
不太活动 | 50(16.1) | 10(12.7) | 8(10.5) | 16(20.5) | 16(20.5) | 6.208 | 0.400 |
轻度活动 | 132(42.4) | 31(39.2) | 36(47.4) | 34(43.6) | 31(39.7) | ||
中度活动 | 129(41.5) | 38(48.1) | 32(42.1) | 28(35.9) | 31(39.7) | ||
独居[n(%)] | 22(7.1) | 6(7.6) | 4(5.3) | 5(6.5) | 7(9.0) | 2.364 | 0.840 |
经常喝绿茶[n(%)] | 49(15.9) | 10(12.8) | 16(21.3) | 10(12.8) | 13(16.7) | 3.784 | 0.423 |
经常喝奶制品[n(%)] | 78(25.2) | 20(25.6) | 20(25.6) | 22(28.2) | 16(20.2) | 3.536 | 0.719 |
吸烟史[n(%)] | 68(22.2) | 19(24.4) | 15(19.7) | 10(13.3) | 24(31.2) | 7.472 | 0.058 |
饮酒史[n(%)] | 58(18.6) | 13(16.5) | 13(17.1) | 11(14.1) | 21(26.9) | 4.952 | 0.175 |
卒中家族史[n(%)] | 32(10.3) | 8(10.0) | 5(6.6) | 12(15.4) | 7(9.0) | 3.490 | 0.324 |
痴呆家族史[n(%)] | 12(3.8) | 2(2.5) | 1(1.3) | 6(7.7) | 3(3.8) | 4.828 | 0.225 |
高血压[n(%)] | 218(70.3) | 51(63.7) | 52(68.4) | 53(67.9) | 63(80.8) | 6.059 | 0.109 |
糖尿病[n(%)] | 86(27.6) | 29(36.3) | 17(22.4) | 19(24.4) | 21(26.9) | 4.468 | 0.215 |
冠心病[n(%)] | 23(7.4) | 6(7.5) | 6(7.9) | 3(3.8) | 8(10.3) | 2.403 | 0.493 |
脑卒中[n(%)] | 5(1.6) | 0(0) | 3(3.9) | 1(1.3) | 1(1.3) | 3.454 | 0.146 |
TIA[n(%)] | 6(1.9) | 3(3.8) | 1(1.3) | 2(2.6) | 0(0) | 2.978 | 0.353 |
高脂血症[n(%)] | 66(21.2) | 9(11.3) | 18(23.7) | 14(17.9) | 25(32.1) | 11.030 | 0.012 |
总胆固醇(mmol/L) | 4.96±0.95 | 4.86±0.95 | 5.04±0.99 | 4.99±0.86 | 4.95±1.00 | 0.540 | 0.655 |
甘油三酯(mmol/L) | 1.67±1.22 | 1.25±0.88 | 1.56±0.79 | 1.80±1.53 | 2.07±1.36 | 6.941 | 0.001 |
肌酐(mmol/L) | 69.47±16.07 | 64.30±15.18 | 70.08±15.01 | 68.00±13.87 | 75.73±18.02 | 7.330 | 0.001 |
阿司匹林药物史 | 20(7.7) | 7(11.5) | 1(1.5) | 3(4.3) | 9(13.8) | 9.362 | 0.025 |
痛风史[n(%)] | 11(3.5) | 1(1.3) | 3(3.9) | 3(3.8) | 4(5.1) | 2.903 | 0.600 |
降尿酸药物史[n(%)] | 6(1.9) | 1(1.3) | 1(1.3) | 3(3.8) | 1(1.3) | 2.748 | 0.564 |
2011年MMSE(分) | 26.63±3.40 | 26.84±3.46 | 27.32±2.96 | 26.05±3.72 | 26.32±3.33 | 2.125 | 0.097 |
2016年MMSE(分) | 24.96±4.82 | 24.83±4.49 | 26.01±3.97 | 23.82±5.77 | 25.23±4.71 | 2.810 | 0.055 |
新发认知功能损害[n(%)] | 43(13.8) | 10(12.5) | 7(9.2) | 17(21.8) | 9(11.5) | 5.992 | 0.112 |
尿酸 | 50~70岁(n=206) | 70~90岁(n=106) | |||||||
---|---|---|---|---|---|---|---|---|---|
新发认知功能损害[n(%)] | 模型3 | 新发认知功能损害[n(%)] | 模型3 | ||||||
OR | 95%CI | P | OR | 95%CI | P | ||||
Q1 | 4/55(7.3) | - | - | - | 6/25(24.0) | - | - | - | |
Q2 | 4/53(7.5) | 1.74 | 0.30~10.14 | 0.537 | 3/23(13.0) | 0.85 | 0.15~4.70 | 0.850 | |
Q3 | 7/46(15.2) | 3.74 | 0.75~18.69 | 0.108 | 10/32(31.3) | 2.51 | 0.63~10.00 | 0.192 | |
Q4 | 0/52(0.0) | - | - | - | 9/26(34.6) | 2.88 | 0.65~12.72 | 0.093 |
尿酸 | 男性(n=124) | 女性(n=188) | |||||||
---|---|---|---|---|---|---|---|---|---|
新发认知功能损害[n(%)] | 模型4 | 新发认知功能损害[n(%)] | 模型4 | ||||||
OR | 95%CI | P | OR | 95%CI | P | ||||
Q1 | 1/32(3.1) | - | - | - | 9/48(18.8) | - | - | - | |
Q2 | 3/30(10.0) | 4.53 | 0.32~63.25 | 0.262 | 4/46(8.7) | 0.78 | 0.18~3.47 | 0.748 | |
Q3 | 4/31(12.9) | 7.85 | 0.56~110.58 | 0.127 | 13/47(27.7) | 1.45 | 0.43~4.90 | 0.551 | |
Q4 | 5/31(16.1) | 18.60 | 1.26~274.13 | 0.033 | 4/47(8.5) | 0.45 | 0.10~2.01 | 0.296 |
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