Impact of maternal hyperthyroidism during pregnancy on neurological and psychiatric development of offspring

doi:10.16138/j.1673-6087.2024.04.10

Abstract

Abstract:

Gestational hyperthyroidism can significantly increase health risks to both mother and fetal. However, there are few reports on its impact on the neuropsychological development of offspring. This article reviews the literature related to the effect of hyperthyroidism during pregnancy on brain structure, intelligence quotient (IQ) and neuropsychiatric disorders of offsprings. It was found that hyperthyroidism during pregnancy may be associated with reduced brain volume and cortical gray matter volume, lower IQ, and increase the risk of depression in offspring. However, its’ relationship with other mental and emotional well-being disorder of the offspring is unclear.

Key words: Pregnancy, Hyperthyroidism, Neurological development, Mental disorders, Offspring

CLC Number:

R581

YANG Ao, ZHANG Peiheng, ZHANG Yang, GAO Ying. Impact of maternal hyperthyroidism during pregnancy on neurological and psychiatric development of offspring[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(04): 269-272.

References 31

[1]	Dong AC, Stagnaro-Green A. Differences in diagnostic criteria mask the true prevalence of thyroid disease in pregnancy: a systematic review and meta-analysis[J]. Thyroid, 2019, 29(2):278-289. doi: 10.1089/thy.2018.0475 pmid: 30444186
[2]	Turunen S, Vääräsmäki M, Lahesmaa-Korpinen AM, et al. Maternal hyperthyroidism and pregnancy outcomes: a population-based cohort study[J]. Clin Endocrinol (Oxf), 2020, 93(6):721-728.
[3]	Xu Y, Li C, Wang W, et al. Gestational and postpartum complications in patients with first trimester thyrotoxicosis: a prospective multicenter cohort study from Northeast China[J]. Thyroid, 2023, 33(6):762-770. doi: 10.1089/thy.2022.0460 pmid: 37051708
[4]	Hizkiyahu R, Badeghiesh A, Baghlaf H, et al. Associations between hyperthyroidism and adverse obstetric and neonatal outcomes: a study of a population database including almost 17,000 women with hyperthyroidism[J]. Clin Endocrinol (Oxf), 2022, 97(3):347-354.
[5]	Korevaar TI, Muetzel R, Medici M, et al. Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study[J]. Lancet Diabetes Endocrinol, 2016, 4(1):35-43.
[6]	Nielsen TC, Nassar N, Shand AW, et al. Association of maternal autoimmune disease with attention-deficit/ hyperactivity disorder in children[J]. JAMA Pediatr, 2021, 175(3):e205487.
[7]	Andersen SL, Andersen S, Vestergaard P, et al. Maternal thyroid function in early pregnancy and child neurodevelopmental disorders: a Danish nationwide case-cohort study[J]. Thyroid, 2018, 28(4):537-546. doi: 10.1089/thy.2017.0425 pmid: 29584590
[8]	Andersen SL, Laurberg P, Wu CS, et al. Maternal thyroid dysfunction and risk of seizure in the child: a Danish nationwide cohort study[J]. J Pregnancy, 2013,2013:636705.
[9]	Instanes JT, Halmøy A, Engeland A, et al. Attention-deficit/hyperactivity disorder in offspring of mothers with inflammatory and immune system diseases[J]. Biol Psychiatry, 2017, 81(5):452-459.
[10]	Rotem RS, Chodick G, Shalev V, et al. Maternal thyroid disorders and risk of autism spectrum disorder in progeny[J]. Epidemiology, 2020, 31(3):409-417. doi: 10.1097/EDE.0000000000001174 pmid: 32251066
[11]	Jølving LR, Nielsen J, Kesmodel US, et al. Chronic diseases in the children of women with maternal thyroid dysfunction: a nationwide cohort study[J]. Clin Epidemiol, 2018,10:1381-1390.
[12]	Pradhan R, Agarwal A, Lombardi CP, et al. Applied embryology of the thyroid and parathyroid glands[M]// Randolph GW. Surgery of the thyroid and parathyroid glands. 3rd ed. Amsterdam: Elsevier, 2021: 15-25.
[13]	Salas-Lucia F, Pacheco-Torres J, González-Granero S, et al. Transient hypothyroidism during lactation alters the development of the corpus callosum in rats. An in vivo magnetic resonance image and electron microscopy study[J]. Front Neuroanat, 2020,14:33.
[14]	Babur E, Altunkaya M, Tufan E, et al. Hyperthyroidism-induced upregulation of neurodegeneration-related gene expression in metaplasticity-induced hippocampus[J]. Neuroendocrinology, 2024, 114(4):400-410. doi: 10.1159/000536045 pmid: 38171345
[15]	Strobl MJ, Freeman D, Patel J, et al. Opposing effects of maternal hypo- and hyperthyroidism on the stability of thalamocortical synapses in the visual cortex of adult offspring[J]. Cereb Cortex, 2017, 27(5):3015-3027.
[16]	Ahmed OM, Ahmed RG, El-Gareib AW, et al. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: Ⅱ-the developmental pattern of neurons in relation to oxidative stress and antioxidant defense system[J]. Int J Dev Neurosci, 2012, 30(6):517-537. doi: 10.1016/j.ijdevneu.2012.04.005 pmid: 22664656
[17]	Jansen TA, Korevaar TIM, Mulder TA, et al. Maternal thyroid function during pregnancy and child brain morphology: a time window-specific analysis of a prospective cohort[J]. Lancet Diabetes Endocrinol, 2019, 7(8):629-637.
[18]	Päkkilä F, Männistö T, Hartikainen AL, et al. Maternal and child’s thyroid function and child’s intellect and scholastic performance[J]. Thyroid, 2015, 25(12):1363-1374. doi: 10.1089/thy.2015.0197 pmid: 26438036
[19]	Nelson SM, Haig C, McConnachie A, et al. Maternal thyroid function and child educational attainment: prospective cohort study[J]. BMJ, 2018,360:k452.
[20]	Ayano G, Demelash S, Gizachew Y, et al. The global prevalence of attention deficit hyperactivity disorder in children and adolescents: an umbrella review of meta-analyses[J]. J Affect Disord, 2023,339:860-866.
[21]	Engel SM, Villanger GD, Herring A, et al. Gestational thyroid hormone concentrations and risk of attention-deficit hyperactivity disorder in the Norwegian mother, father and child cohort study[J]. Paediatr Perinat Epidemiol, 2023, 37(3):218-228.
[22]	Asherson P, Agnew-Blais J. Annual research review: does late-onset attention-deficit/hyperactivity disorder exist?[J]. J Child Psychol Psychiatry, 2019, 60(4):333-352. doi: 10.1111/jcpp.13020 pmid: 30843223
[23]	Rocco I, Corso B, Bonati M, et al. Time of onset and/or diagnosis of ADHD in European children: a systematic review[J]. BMC Psychiatry, 2021, 21(1):575. doi: 10.1186/s12888-021-03547-x pmid: 34784913
[24]	Varghese M, Keshav N, Jacot-Descombes S, et al. Autism spectrum disorder: neuropathology and animal models[J]. Acta Neuropathol, 2017, 134(4):537-566. doi: 10.1007/s00401-017-1736-4 pmid: 28584888
[25]	Brown AS, Surcel HM, Hinkka-Yli-Salomäki S, et al. Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2015,57:86-92.
[26]	Andersen SL, Laurberg P, Wu CS, et al. Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study[J]. BJOG, 2014, 121(11):1365-1374.
[27]	Levie D, Korevaar TIM, Bath SC, et al. Thyroid function in early pregnancy, child IQ, and autistic traits: a meta-analysis of individual participant data[J]. J Clin Endocrinol Metab, 2018, 103(8):2967-2979. doi: 10.1210/jc.2018-00224 pmid: 29757392
[28]	Fetene DM, Betts KS, Alati R. The role of maternal prenatal thyroid function on offspring depression: findings from the ALSPAC cohort[J]. Dev Psychopathol, 2020, 32(1):189-196. doi: 10.1017/S0954579418001657 pmid: 30688193
[29]	MacSweeney D, Timms P, Johnson A. Thryo-endocrine pathology, obstetric morbidity and schizophrenia: survey of a hundred families with a schizophrenic proband[J]. Psychol Med, 1978, 8(1):151-155. pmid: 635067
[30]	Petersen TG, Andersen AN, Uldall P, et al. Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study[J]. BMC Pediatr, 2018, 18(1):181. doi: 10.1186/s12887-018-1152-5 pmid: 29855286
[31]	Kinomoto-Kondo S, Umehara N, Sato S, et al. The effects of gestational transient thyrotoxicosis on the perinatal outcomes: a case-control study[J]. Arch Gynecol Obstet, 2017, 295(1):87-93. doi: 10.1007/s00404-016-4219-2 pmid: 27766407