Research progress on biomarkers for chronic obstructive pulmonary disease complicated with obstructive sleep apnea

doi:10.16138/j.1673-6087.2024.05.07

Abstract

Abstract:

The coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is referred to as COPD-OSA overlap, also known as overlap syndrome (OS). OS patients are more severe and have worse prognosis than those with OSA and COPD alone. Because pulmonary function and polysomnography cannot be conducted widely for patients, at present, there are many research to explore the clinical value of immunology, blood cell, gene protein，body fluid and other related biomarkers related to OS in assisting diagnosis, predicting the risk and severity of disease. This article reviews the recent research progress on OS-related biological markers.

Key words: Overlapping syndrome, Biomarkers, Chronic obstructive pulmonary disease, Obstructive sleep apnea

CLC Number:

R563.5

QIANG Shihao, DAI Qingxia, HUANG Lina, GUO Hua, CUI Xiaochuan. Research progress on biomarkers for chronic obstructive pulmonary disease complicated with obstructive sleep apnea[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(05): 322-327.

Figures/Tables 1

References 45

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项目	辅助诊断	发病风险	疾病严重程度	治疗评估	预后评估
TNF-α	√		√
VCAM-1	√		√
T淋巴细胞亚群	√	√		√	√
CRP和IL-6	√
红细胞		√
NLR	√				√
MPV和PDW			√
sestrin2	√
FPR1			√
Lp-PLA2	√		√
MMP-9			√
MUC5AC	√
粪球菌属2		√
BMI		√
Vit D	√