A case of neuropsychiatric lupus successfully treated with sequential therapy of rituximab and belimumab therapy

doi:10.16138/j.1673-6087.2025.04.10

Abstract

Abstract:

Neuropsychiatric lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus, it leads to a significantly increased mortality rate when it affects the central nervous system. Currently, there is no established standard treatment regimen for this condition. This article reports a case study of a patient with NPSLE, who primarily presented abnormal mental and behavioral and incoherent speech. Following sequential treatment with rituximab and belimumab, the patient’s symptoms were relieved and laboratory imaging indicators were significantly improved, which provided a new potential therapeutic strategy for NPSLE.

Key words: Systemic lupus erythematosus, Neuropsychiatric lupus erythematosus, Rituximab, Belimumab

CLC Number:

R593.2

CHEN Xue, SUN Mingfang, DAI Huanzi. A case of neuropsychiatric lupus successfully treated with sequential therapy of rituximab and belimumab therapy[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(04): 316-318.

Figures/Tables 2

References 18

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