Journal of Internal Medicine Concepts & Practice ›› 2026, Vol. 21 ›› Issue (01): 59-61.doi: 10.16138/j.1673-6087.2026.01.08

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Olverembatinib combined with inotuzumab ozogamicin in Philadelphia chromosome-positive acute lymphoblastic leukemia with multiple relapses: a case report

LIU Heng(), XI Rui, PAN Yaozhu, WANG Zonghui, TIAN Hongjuan, MAO Dongfeng, WU Tao*()   

  1. Department of Hematology, the 940th Hospital of the Joint Logistic Support Force of the People’s Liberation Army of China, Lanzhou 730050, China
  • Received:2025-02-19 Online:2026-02-25 Published:2026-04-08

Abstract:

Relapsed/refractory (R/R) Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is difficult to treat, facing a poor prognosis and short overall survival. The usage of tyrosine kinase inhibitor (TKI) and immunotherapy has brought new hope for the treatment of R/R Ph+ ALL for patients. This paper retrospectively analyzed a patient with Ph+ ALL experiencing multiple relapses, who was treated with olverembatinib in combination with a reduced dose of inotuzumab ozogamicin. The patient achieved complete response (CR) and minimal residual disease (MRD) negativity upon reexamination two months later, attaining a near-complete molecular response (CMR). A review of relevant literature is included to provide clinical treatment experience.

Key words: olverembatinib, inotuzumab ozogamicin, relapsed/refractory, Philadelphia chromosome-positive acute lymphoblastic leukemia

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