雌激素是新疆女性胆石病人的危险因素

doi:10.16139/j.1007-9610.2021.03.017

摘要/Abstract

摘要：

目的：探讨雌激素水平是新疆女性胆石病人的危险因素。方法：比较204例女性胆石组病人与204例对照组病人的雌二醇、促黄体生成素、卵泡刺激素、睾酮、孕酮、催乳素水平,以研究胆石形成的危险因素。结果：胆石组病人与对照组比较,促黄体生成素、卵泡刺激素、睾酮、孕酮、催乳素水平,差异均无统计学意义。与对照组比较,胆石组病人雌二醇育龄期和绝经后水平均升高,差异有统计学意义。胆石病人多发结石与单发结石比较,促黄体生成素、卵泡刺激素、睾酮、孕酮、催乳素水平差异均无统计学意义,雌二醇水平升高,差异有统计学意义。结论：育龄期和绝经后女性病人血清雌激素含量升高,多发胆石组女性病人血清雌激素含量高于单发结石病人。研究提示,血清雌激素升高是胆石的危险因素,为胆石形成机制之一。

关键词: 女性雌激素, 胆石病, 危险因素, 成石机制

Abstract:

Objective To investigate estrogen as one of risk factors in women with gallstone in Xinjiang. Methods Estradiol, luteinizing hormone(LH), follicle-stimulating hormone(FSH), testosterone, progesterone, and prolactin in 204 women with gallstone were compared with those in 204 control patients without gallstone. Results There were no statistically significant differences in LH, FSH, testosterone, progesterone and prolactin levels between Xinjiang female patients with gallstone and the patients in control group and between female patients with single stone and those with multiple stones. Estradiol level increased statistically significant both premenopausal women and postmenopausal women when compared with controls women. Higher estradiol level was found in female patients of multiple gallstones compared with that in female patients of single gallstone with statistically significant difference. Conclusions There was increase in serum estrogen of premenopausal and postmenopausal women combined with the higher estrogen level in women with multiple gallstones than those with single gallstone, which indicated the increasing in serum estrogen may be risk factor for gallstone disease and the pathogenesis of gallstone disease.

Key words: Female estrogen, Gallstone disease, Risk factor, Pathogeneses

中图分类号:

R575.62

阿扎提江·艾尼瓦尔, 阿卜杜外力·艾尔肯, 玉苏甫, 于文庆, 克力木. 雌激素是新疆女性胆石病人的危险因素[J]. 外科理论与实践, 2021, 26(03): 259-261.

Azatijiang Ainiwaer, Abuduwaili Aierken, YU Sufu, YU Wenqing, Kelimu . Estrogen: risk factor for Xinjiang female patients with gallstone[J]. Journal of Surgery Concepts & Practice, 2021, 26(03): 259-261.

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指标	研究组(n=95)	对照组(n=71)	t值	P值
促黄体生成素	12.37±12.17	11.22±10.09	1.123	0.262
雌二醇	96.81±42.88	64.69±24.00	2.056	0.040
卵泡刺激素	20.89±16.91	25.24±16.45	0.910	0.363
催乳素	20.11±13.23	17.86±11.49	1.642	0.298
睾酮	0.21±0.15	0.24±0.17	0.611	0.485
孕酮	3.8±3.04	3.28±3.10	0.807	0.419

指标	研究组(n=109)	对照组(n=133)	t值	P值
促黄体生成素	26.56±14.08	26.33±12.64	0.310	0.975
雌二醇	46.91±37.97	32.80±26.51	4.283	<0.001
卵泡刺激素	59.73±30.39	62.88±34.16	0.203	0.839
催乳素	17.43±12.89	15.24±7.49	0.682	0.935
睾酮	0.31±0.29	0.30±0.20	0.796	0.426
孕酮	0.63±0.61	0.45±0.30	1.435	0.151

组别	单发	多发	t/χ²值	P值
例数	51	153
育龄期/绝经后（n）	34/17	61/92	11.219	0.001
促黄体生成素	11.96±9.53	13.26±9.56	1.643	0.102
雌二醇	41.99±28.81	49.64±25.15	3.147	0.002
卵泡刺激素	35.36±31.74	29.63±28.05	0.781	0.432
催乳素	14.27±9.70	15.04±9.71	0.418	0.676
睾酮	0.30±0.16	0.26±0.18	0.088	0.930
孕酮	1.21±0.95	1.91±1.09	0.447	0.655