口服利福平联合超声引导穿刺治疗肉芽肿小叶性乳腺炎的回顾性研究

doi:10.16139/j.1007-9610.2021.06.019

摘要/Abstract

摘要：

目的：研究口服利福平联合超声穿刺治疗肉芽肿小叶性乳腺炎（granulomatous lobular mastitis, GLM）的疗效。方法：收集2017年1月至2019年1月我院收治经粗针穿刺病理诊断为GLM的10例病人临床资料，中位年龄为34岁。分析口服利福平（剂量为每天2次，每次300 mg，疗程为9个月）联合超声穿刺抽脓治疗3、6、9、12个月后的临床症状和超声检查结果。结果：所有病人均有母乳喂养史。有急性期乳房表现和局部病变，5例伴乳房脓肿。治疗12个月后，随访所有病人临床症状均消失，且超声检查结果正常。随访12个月内未见复发。结论：口服利福平联合超声穿刺治疗GLM病人效果显著。

关键词: 肉芽肿小叶性乳腺炎, 利福平, 超声引导穿刺

Abstract: Objective To study the efficacy of oral administration of rifampicin combined with ultrasound-guided puncture for granulomatous lobular mastitis (GLM). Methods From January 2017 and January 2019，10 GLM patients with median age of 34 years confirmed by pathology were included in this study and treated with oral administration of rifampicin, 300 mg twice daily for a period of 9 months, combined with ultrasound-guided puncture. The symptoms and ultrasound manifestations of GLM patients were investigated at 3, 6, 9, 12 months, respectively. Results All patients had a history of breast feeding and manifestation of acute stages of breast infection, 5 cases with breast abscess. After 12 months therapy, the symptoms disappeared in all patients with normal ultrasonic manifestation and no patient relapsed. Conclusions Oral administration of rifampicin combined with ultrasound-guided puncture could be effective in the treatment of GLM patients.

Key words: Granulomatous lobular mastitis, Rifampicin, Ultrasound-guided puncture

中图分类号:

R655.8

仇伊尔, 邬颖杰, 仇骞慧, 陆国文. 口服利福平联合超声引导穿刺治疗肉芽肿小叶性乳腺炎的回顾性研究[J]. 外科理论与实践, 2021, 26(06): 556-560.

QIU Yier, WU Yingjie, QIU Qianhui, LU Guowen. Retrospective study on oral administration of rifampicin combined with ultrasound-guided puncture in treatment of granulomatous lobular mastitis[J]. Journal of Surgery Concepts & Practice, 2021, 26(06): 556-560.

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项目	确诊	3个月	6个月	9个月	12个月
临床症状
可触及的乳房肿块	10	7	3	0	0
乳房表面红肿	10	4	2	1	0
乳房疼痛	10	3	1	0	0
乳房溃疡	4	2	1	0	0
乳房瘘管	2	1	0	0	0
乳头溢液	4	2	0	0	0
B超影像学检查表现
不规则低回声区	10	7	4	1	0
囊状或管状液性暗区	5	2	1	0	0
腋窝淋巴结肿大	8	1	0	0	0