外科理论与实践 ›› 2023, Vol. 28 ›› Issue (01): 17-23.doi: 10.16139/j.1007-9610.2023.01.03
收稿日期:
2022-11-08
出版日期:
2023-01-25
发布日期:
2023-03-27
通讯作者:
田艳涛
E-mail:tianyantao@cicams.ac.cn
LU Yiming, XIONG Jianping, TIAN Yantao()
Received:
2022-11-08
Online:
2023-01-25
Published:
2023-03-27
Contact:
TIAN Yantao
E-mail:tianyantao@cicams.ac.cn
摘要:
晚期胃癌的治疗一直是胃癌治疗中的难点。Ⅳ期胃癌由于存在转移灶,往往难以达到根治性切除。转化治疗是指通过化疗、靶向治疗、免疫治疗等非外科手段,使肿瘤退缩甚至部分局部病灶消失,从而使得初始难以行根治性手术的病人获得R0切除机会。目前晚期胃癌的治疗仍以姑息手术和对症治疗为主,晚期胃癌的转化治疗尚未形成共识。评价胃癌转化治疗效果的主要指标是转化治疗后R0切除率、疾病控制率以及客观缓解率等实体瘤的疗效评价标准(response evaluation criteria in solid tumor, RECIST)。不同治疗手段和方案的疗效各异。转化治疗的最终目的是争取R0手术机会,故转化治疗后手术的合理实施也是关键问题。Yoshida提出的四分类法是目前最为普遍接受的手术决策依据。目前晚期胃癌的转化治疗仍困难重重,缺乏高质量研究。深入研究肿瘤微环境和开发新的治疗方法或许是今后研究的大方向。
中图分类号:
卢一鸣, 熊建平, 田艳涛. 晚期胃癌转化治疗的发展现状与研究前景[J]. 外科理论与实践, 2023, 28(01): 17-23.
LU Yiming, XIONG Jianping, TIAN Yantao. Current status and prospect of conversion therapy for far-advanced gastric cancer[J]. Journal of Surgery Concepts & Practice, 2023, 28(01): 17-23.
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