胆道恶性肿瘤分型新进展

doi:10.16139/j.1007-9610.2024.02.04

摘要/Abstract

摘要：

胆道恶性肿瘤是一种基因组、表观遗传修饰和分子表达模式上存在高度异质性的肿瘤。即使相同病理形态和临床分期的胆道恶性肿瘤病人对治疗的反应和预后也存在巨大差异。传统病理组织学分型和临床分型已不能满足精准医学时代的需求。分子分型能提供更个性化的癌症治疗方案，不仅有助于揭示肿瘤的发展机制并准确预测疾病的预后，且对于指导新型靶向药物的开发以及实施针对性肿瘤治疗发挥重要作用。随着精准医学的发展，分子分型在癌症诊断、治疗选择和预后评估中的作用日益增强。笔者就近年来国内、外临床和基础的研究进展，系统阐述胆道恶性肿瘤的分型进展。

关键词: 胆道恶性肿瘤, 临床分型, 病理组织学分型, 分子分型, 精准治疗

Abstract:

Biliary tract carcinoma exhibits high heterogeneity at the genomic, epigenetic, and molecular expression levels. The patients even with the same pathological morphology and clinical stage of biliary tract malignant tumors have substantial differences in the treatment response and prognosis. Traditional pathological histology and clinical classifications are no longer sufficient to meet the demands of the precision medicine era. Molecular subtyping has the potential to provide more personalized cancer treatment strategies. It not only helps to reveal the mechanisms of tumor development and accurately predict disease prognosis, but also plays a crucial role in guiding the development of novel targeted drugs and implementing targeted therapies for specific tumors. With the ongoing development of precision medicine, the role of molecular subtyping in cancer diagnosis, treatment option, and prognosis assessment is increasingly prominent. This paper systematically reviewed the recent progress in the molecular subtyping of biliary tract malignant tumors based on domestic and international clinical and basic research.

Key words: Biliary tract carcinoma, Clinical classification, Pathological histology classification, Molecular subtyping, Precision therapy

中图分类号:

R735.8

林志文, 刘红枝, 曾永毅. 胆道恶性肿瘤分型新进展[J]. 外科理论与实践, 2024, 29(02): 114-120.

LIN Zhiwen, LIU Hongzhi, ZENG Yongyi. Recent advances in subtyping of biliary tract carcinoma[J]. Journal of Surgery Concepts & Practice, 2024, 29(02): 114-120.

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