MicroRNA-21 higher expression in cancer tissues elevates lymph node metastasis: a meta-analysis

doi:10.16139/j.1007-9610.2018.03.016

Abstract

Abstract: Objective: To explore the association of abnormal microRNA-21(miR-21) expression in cancer tissues with lymph node metastasis. Methods: We searched PubMed, Web of Science, EMbase and CBM databases until October 2017 to retrieve the relevant articles on miR-21 expression in cancer tissues and lymph node metastasis. Random-effects model was adopted to calculate OR and 95%CI of the risk of lymph node metastasis in the group of miR-21 higher expression and the group of lower expression. The statistical analyses including heterogeneity tests, sensitivity analysis and publication bias were performed in this meta-analysis. Results: A total of 16 studies involving 1 492 cases revealed that higher expression of miR-21 in cancers was found to be associated with lymph node metastasis (pooled OR=2.01, 95%CI=1.36-2.97, P<0.001). According to subgroup analysis, it was indicated that miR-21 higher expression was significantly related to the risk of lymph node metastasis for cancer in digestive system (OR=2.22, 95%CI=1.49-3.30), bladder cancer and cervical cancer (OR=5.48, 95%CI=1.84-16.30), <60 cases (OR=2.39, 95%CI=1.44-3.98), ≥60 cases (OR=1.78, 95%CI=1.04-3.05), respectively. Conclusions: It is shown in this meta-analysis that the risk of lymph node metastasis in patients was associated with higher miR-21 expression. The subgroup analysis indicated that miR-21 expression may serve as a mole-cular marker for lymph node metastasis in digestive system tumors and bladder cancer and cervical cancer.

Key words: miR-21, Cancer tissue, Lymph node metastasis, Meta-analysis

CLC Number:

R73-37

HONG Yongzhi, LIU Xiaoyang, WANG Jin, ZHAO Liang, ZHAO Peng. MicroRNA-21 higher expression in cancer tissues elevates lymph node metastasis: a meta-analysis[J]. Journal of Surgery Concepts & Practice, 2018, 23(03): 263-270.

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