Abstract: Objective To analyze the patients of Graves′ disease with thyroid cancer retrospectively for reference of standardized treatment. Methods Forty-seven patients diagnosed Graves′ disease with thyroid cancer were treated between January 2013 and October 2017. Clinical data, treatments and short outcomes by follow-up were analyzed. Comparison was conducted between 47 cases and thyroid cancer cases without Graves′ disease during same period in our hospital. Results There were 86 cases with Graves′ disease among whom 47(54.7%) were combined with thyroid cancer. It was found that 25 (53.2%) cases with thyroid cancer had Graves′ disease less than 12 months and 11 (23.4%) cases had both 13-48 months and more than 48 months respectively. All 47 cases were performed operations uneventfully. Preoperative potassium iodide was given only 5 cases. No thyroid crisis occurred, and there was no permanent hypoparathyroidism or permanent nerve injury. Only two cases were found cervical lymph node metastasis during the follow-up period of median 14 months. There was no significant difference between the cases with and without Graves′ disease in terms of thyroid microcarcinoma, multifocal tumors and central, lateral lymph node metastasis. Conclusions Graves′ disease with thyroid cancer might not be rare. Increased risk of thyroid cancer was present in patients with shorter course of Graves′ disease. Graves′ disease might not have a significant influence on the aggressiveness of thyroid cancer. The prognosis of thyroid cancer with Graves′ disease is generally favorable.

Key words: Graves'disease, Thyroid cancer, Clinical feature, Prognosis