Abstract: Objective To investigate the location of gastric remnant cancer associated with clinicopathological features and prognosis of the patients with gastric remnant cancer. Methods Retrospective analysis was performed for 147 patients with gastric remnant cancer dividing into anastomotic group (90 cases) and non anastomotic group (57 cases) based on tumor in anastomotic area or not, who admitted to Ruijin Hospital Shanghai Jiao Tong University School of Medicine from January 2007 to December 2016. Clinicopathological characteristics and prognosis were compared between two groups. Results The patients in anastomotic group had longer interval from initial partial gastrectomy than that of patients in non anastomotic group [(245.29±189.53) months vs (157.66±149.11) months, P=0.004]. Patients in anastomotic group were associated with higher reconstruction of Billroth Ⅱ (71.4% vs 42.9%, P=0.001), higher distant metastasis (31.1% vs 12.3%, P=0.009) and lower rate of radical surgery (67.8% vs 84.2%, P=0.027) compared with patients in non anastomotic group. Three year survival rates was 30.0% and 55.6% for anastomotic group and non anastomotic group (P=0.006) and 5 year survival rate 4.4% and 28.1% respectively (P<0.001). It was shown by Kaplan-Meier curve that survival duration was significantly shorter in anastomotic group than in non anastomotic group (P=0.007). Conclusions Gastric remnant cancer located at anastomotic area was in later TNM staging, more distant metastasis, lower rate of radical resection and poorer prognosis compared with those at non anastomotic area.

Key words: Gastric remnant cancer, Tumor location, Anastomotic site, Prognosis