Abstract: Objective To study the efficacy of oral administration of rifampicin combined with ultrasound-guided puncture for granulomatous lobular mastitis (GLM). Methods From January 2017 and January 2019，10 GLM patients with median age of 34 years confirmed by pathology were included in this study and treated with oral administration of rifampicin, 300 mg twice daily for a period of 9 months, combined with ultrasound-guided puncture. The symptoms and ultrasound manifestations of GLM patients were investigated at 3, 6, 9, 12 months, respectively. Results All patients had a history of breast feeding and manifestation of acute stages of breast infection, 5 cases with breast abscess. After 12 months therapy, the symptoms disappeared in all patients with normal ultrasonic manifestation and no patient relapsed. Conclusions Oral administration of rifampicin combined with ultrasound-guided puncture could be effective in the treatment of GLM patients.

Key words: Granulomatous lobular mastitis, Rifampicin, Ultrasound-guided puncture