Reflections on key issues in neoadjuvant therapy for pancreatic cancer: a paradigm shift from evidence-based medicine to precision medicine

doi:10.16139/j.1007-9610.2025.06.03

Abstract

Abstract:

Neoadjuvant therapy for pancreatic cancer is undergoing a paradigm shift from conventional chemotherapy to precision medicine. This expert forum discussed cutting-edge issues in pancreatic cancer neoadjuvant therapy from an evidence-based perspective, incorporating the latest clinical research advances. We focused on innovative directions including immunotherapy combination strategies, liquid biopsy applications, artificial intelligence (AI)-assisted decision making, and individualized precision medicine. We proposed forward-looking concepts such as molecular subtyping-guided individualized treatment strategies, multi-omics integrated efficacy prediction models, and standardized multidisciplinary collaborative care systems. These innovative concepts will drive pancreatic cancer neoadjuvant therapy toward more precise and effective directions.

Key words: Pancreatic cancer, Neoadjuvant therapy, Precision medicine, Immunotherapy, Liquid biopsy, Artificial intelligence（AI）

CLC Number:

R735.9

KANG Xiaochao, LI Yikai, GUO Shiwei, JIN Gang. Reflections on key issues in neoadjuvant therapy for pancreatic cancer: a paradigm shift from evidence-based medicine to precision medicine[J]. Journal of Surgery Concepts & Practice, 2025, 30(06): 474-478.

References 30

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