Combination of targeted multikinase inhibitor and radioiodine: a new strategy of treatment for advanced differentiated thyroid carcinoma

doi:10.16139/j.1007-9610.2023.06.06

Abstract

Abstract:

Advanced differentiated thyroid carcinoma (ADTC) lacks effective treatment options, and has a poor prognosis, which is an urgent clinical problem to be resolved. Targeted multikinase inhibitor(MKI) has been approved for the treatment of radioiodine refractory differentiated thyroid carcinoma, and have recently been recommended as a preoperative neoadjuvant therapy agents for locally ADTC. Although radioiodine therapy is the standard postoperative treatment for ADTC, it has certain limitations. MKI combined with radioiodine therapy is expected to become a new strategy of treatment for ADTC.

Key words: Advanced differentiated thyroid carcinoma, Multikinase inhibitor, Radioiodine, ¹³¹I

CLC Number:

R736.1

LIU Wei. Combination of targeted multikinase inhibitor and radioiodine: a new strategy of treatment for advanced differentiated thyroid carcinoma[J]. Journal of Surgery Concepts & Practice, 2023, 28(06): 520-523.

Figures/Tables 1

References 28

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特征分类	特征描述
结构/外科	巨大、侵袭性或不可手术的原发颈部病灶、区域性转移或复发性疾病；远处转移包括纵隔转移；颈部残留病灶不适合再次手术；影像学表现为快速进展或倍增时间<6个月；肿瘤的生长即将造成威胁
生化	不摄取放射性碘或放射性碘治疗疗效不佳；TSH抑制的情况下（TSH<0.1 mU/L）疾病仍进展；甲状腺球蛋白(thyroglobulin, Tg)倍增时间<6个月
组织学/分子	分化差或侵袭性病理亚型（如柱状、高细胞、靴钉样等）；Ki-67指数高；高核分裂象计数/肿瘤坏死
临床判断	临床医师认定的其他侵袭性行为