Journal of Surgery Concepts & Practice ›› 2023, Vol. 28 ›› Issue (06): 524-528.doi: 10.16139/j.1007-9610.2023.06.07
• Original article • Previous Articles Next Articles
LIAO Zhenyu, ZHAO Qiwu, KUANG Jie, LIU Zhuoran, SUN Hanxing, WANG Yue, QIU Weihua, CHEN Xi, YAN Jiqi()
Received:
2023-09-18
Online:
2023-11-25
Published:
2024-03-04
CLC Number:
LIAO Zhenyu, ZHAO Qiwu, KUANG Jie, LIU Zhuoran, SUN Hanxing, WANG Yue, QIU Weihua, CHEN Xi, YAN Jiqi. Study on invasive histopathological features of papillary thyroid carcinoma with tall cell variant[J]. Journal of Surgery Concepts & Practice, 2023, 28(06): 524-528.
Tab 1
The histological classification of PTC[n(%)]
Histological classification | Number |
---|---|
Classic PTC | 15 578(81.26) |
Follicular variant | 1 906(9.94) |
Tall cell variant | 1 380(7.20) |
Diffuse Sclerosing | 414(2.16) |
Warthin-like | 65(0.34) |
Solid/trabecular variant | 63(0.33) |
Hobnail variant | 36(0.19) |
Oncocytic variant | 20(0.10) |
Columnar cell variant | 5(0.03) |
Encapsulated variant | 5(0.03) |
Tab 2
Patient baseline information[$\bar{x}\pm s$/n(%)]
Item | cPTC (n=15 578) | TCV-PTC (n=1 380) | t/χ2 value | P value |
---|---|---|---|---|
Age | 42.1±11.8 | 44.3±12.3 | 6.62 | <0.001 |
Gender [n(%)] | ||||
Female | 11 545(74.1) | 1 027(74.4) | 0.06 | 0.801 |
Male | 4 033(25.9) | 353(25.6) | ||
Original surgical approach [n(%)] | ||||
Hemithyroidectomy and selective neck dissection | 11 507(73.9) | 932(67.5) | 25.99 | <0.001 |
Total thyroidectomy | 4 071(26.1) | 448(32.5) | ||
Radical neck dissection [n(%)] | ||||
Yes | 1 247(8.0) | 197(14.3) | 63.98 | 0.001 |
No | 14 331(92.0) | 1 183(85.7) |
Tab 3
Invasive features of cPTC and TCV-PTC [$\bar{x}\pm s$/n(%)]
Item | cPTC (n=15 578) | TCV-PTC (n=1 380) | t/χ2 value | P value |
---|---|---|---|---|
Extrathyroidal extension [n(%)] | ||||
Yes | 6 012(38.6) | 1 140(82.6) | 1 007 | <0.001 |
No | 9 566(61.4) | 240(17.4) | ||
Nerve invasion [n(%)] | ||||
Yes | 87(0.6) | 32(2.3) | 56.38 | <0.001 |
No | 15 491(99.4) | 1 348 (97.7) | ||
Lymphovascular invasion [n(%)] | ||||
Yes | 49(0.3) | 16(1.2) | 23.70 | <0.001 |
No | 15 529(99.7) | 1364(98.8) | ||
Multifocality [n(%)] | ||||
Yes | 3 401(21.8) | 356(25.8) | 11.56 | 0.001 |
No | 12 177(78.2) | 1024(74.2) | ||
Maximal tumor diameter (cm) | 0.77±0.58 | 1.29±0.72 | 31.24 | <0.001 |
Lymph node positivity [n(%)] | ||||
Yes | 6 571(42.2) | 742(53.8) | 69.39 | <0.001 |
No | 9 007(57.8) | 638(46.2) | ||
BRAF mutation [n(%)] | ||||
Yes | 6 451(79.2) | 892(93.6) | 113.6 | <0.001 |
No | 1 694(20.8) | 61(6.4) | ||
Combined Hashimoto thyroiditis [n(%)] | ||||
Yes | 2 118(13.6) | 144(10.4) | 10.96 | <0.001 |
No | 13 460(86.4) | 1236(89.6) |
Tab 4
Lymph node metastasis status of cPTC and TCV-PTC[$\bar{x}\pm s$/n(%)]
Item | cPTC (n=15 578) | TCV-PTC (n=1 380) | t/Z/χ2 value | P value |
---|---|---|---|---|
Central lymph nodes positivity [n(%)] | ||||
Yes | 6 389(41.0) | 719(52.1) | 64.02 | <0.001 |
No | 9 189(59.0) | 661(47.9) | ||
Maximum diameter of central lymph nodes metastasis (mm) | 2.90±2.46 | 3.34±2.89 | 3.14 | 0.002 |
The number of positive central lymph nodes | 2.93±2.66 | 3.32±3.03 | -3.34 | 0.001 |
Lateral neck lymph nodes positivity [n(%)] | ||||
Yes | 1 092(7.0) | 175(12.7) | 58.98 | <0.001 |
No | 14 486(93.0) | 1 205(87.3) | ||
Maximum diameter of lateral neck lymph nodes metastasis (mm) | 7.84±5.40 | 9.06±6.05 | 1.85 | 0.065 |
The number of positive lateral neck lymph nodes | 4.24±3.56 | 4.95±3.78 | -2.56 | 0.010 |
Bilateral neck lymph nodes positivity [n(%)] | ||||
Yes | 56(0.4) | 9(0.7) | 2.85 | 0.092 |
No | 15 522(99.6) | 1 371(99.3) |
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