Abstract: The development of bone tissue engineering provides a promising way to repair large segment of bone defects. And it has already showed tremendous potential for application on the basis of numerous animal experiments and rising clinic studies. However, osteogenesis of the tissue engineered bone （TEB） grafts may be unstable after TEB constructs implanted in vivo, especially in sites with poor blood supply. Recent studies have demonstrated that the vascularization of TEB plays a vital role in generating large segment of bone grafts. In this article, the advances of TEB vascularization strategy were reviewed.

Key words: Tissue engineered bone, Bone defect, Vascularization