Abstract: Objective To explore the etiology, clinical features and treatment strategies of secondary cleft lip resulting from ulcerated hemangiomas. Methods A retrospective analysis of IH from Dec 2012 to Jan 2014 was performed. The etiology, clinical features and treatment strategies of secondary cleft lip resulting from ulcerated hemangiomas were analyzed. Results The medical records of 528 IH were examined. 33 IH (20 girls and 13 boys) located in lip area. Only 3 developed ulceration, and 2 of 3 resulted in secondary complete cleft lip, both girls. Propranolol was used at 2 mg/kg/d to treat the IH just one week after ulceration, the cleft lip inevitably happened after medicine therapy. Both patients received surgical repair of cleft lip and obtained good results. Conclusion Cleft lip is a rare complication of ulcerated hemangioma. Propranolol can not prevent cleft lip after the ulceration of IH absolutely. An early stage repair surgery at the beginning of involuting phase is more helpful in reducing pain and uncomfortable of both physical and psychological than the repair after an absolute involution.

Key words: Infant hemangioma, Ulceration, Cleft lip, Propranolol