Skin γδT-Cell Functions in Epithelium Integrity and Wound Healing

doi:10.3969/j.issn.1673-0364.2017.06.015

Abstract

Abstract: The research showed that the dendritic epidermal γδ T cells (DETCs) found in murine skin expressed aγδTCR composed of Vγ3Jγ1-Cγ1and Vδ1Dδ2Jδ2-Cδ chains which specifically expressed in murine skin. Activated DETCs produce several cytokines, growth factors and chemokines. All these factors were related to tissue repair, cell survival, proliferation, migration, recruitment, and play a key role in maintaining the epithelium integrity and repairing the epithelial tissue. In this paper, the functions of DETCs in maintaining the epithelium integrity and would repair were reviewed.

Key words: γδT cell, Epithelium integrity, Tissue repair, Skin

CLC Number:

R622

WANG Peihe,HE Zeliang,LI Xiaodong,AN Liang'en,ZHUO Qinqiang,LIU Lingling. Skin γδT-Cell Functions in Epithelium Integrity and Wound Healing[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2017, 13(6): 354-356.

[1]	PAN Fuquan1 (潘福全), PAN Haitao1 (泮海涛), ZHANG Lixia1∗ (张丽霞), LU Linjun2 (陆林军), YANG Xiaoxia1 (杨晓霞), WANG Lin1 (王琳). Analysis of Driving Psychological Load in V-Shaped Subsea Tunnels Considering Driver Skin Electrical Signals [J]. J Shanghai Jiaotong Univ Sci, 2022, 27(4): 579-587.
[2]	LI Ming, GUO Zhaodi, WANG Wei, CHEN Dongsheng, LI Tao.. Clinical effect of bilayer artificial dermis combined with autologous skin graft for repairing finger skin soft tissue defect with tendon and bone exposure [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2022, 18(4): 322-.
[3]	CHEN Lu (陈露), CHENG Liying (程丽英), CHEN Tian (陈田), ZHANG Yuguang (张余光), ZHANG Jianming* (张建明). Macrophage Polarization in Skin Wound Healing: Progress in Biology and Therapeutics [J]. J Shanghai Jiaotong Univ Sci, 2022, 27(2): 264-280.
[4]	YU Mingwei, WANG Min, WANG Qian, et al. Application of low skin paddle pedicled latissimus dorsi myocutaneous flap in repairing the deep soft tissue defect of the shoulder, back and upper limb [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2022, 18(2): 111-.
[5]	CHEN Chuan, PAN Jiadong, HUANG Yaopeng, et al. Transplantation of flap with lymph nodes in the treatment of lower extremity lymphedema　 [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2022, 18(1): 4-.
[6]	QIAO Yi, LI Chen, ZHAO Ren, XI Beihua. Evaluation of stoma skin barrier in peristomal wound healing [J]. Journal of Surgery Concepts & Practice, 2021, 26(01): 72-75.
[7]	CHEN Le，WANG Ying，LI Haihua. A New Electronic Skin with High Sesitivity Based on Sandwich Structure [J]. Journal of Shanghai Jiaotong University, 2020, 54(5): 499-506.
[8]	Qianqian HAN, Mingyue QU, Bin XUE, Chunren WANG. Evaluation of Three Kinds of Skin Repair Materials on the Effectiveness of Skin Injury Repair in Diabetic Rats [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2020, 16(3): 232-236.
[9]	Ying HUANG, Weiwei BIAN. Preparation and Evaluation of Psychological Resilience Assessment Tool for Adolescent Patients Undergoing Neck Scar Resection and Skin Grafting [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2020, 16(3): 245-249.
[10]	CHEN Xiaoying, ZHENG Jie. Establishment of pretibial myxedema severity and activity rating scale and validation with ultrasonic and laboratory measurements [J]. Journal of Diagnostics Concepts & Practice, 2020, 19(03): 243-247.
[11]	HOU Junjie,LIU Chang,CHEN Fengchao,ZHANG Siya,YAN Tongtong,JIA Yulei. Application of Nasolabial Flap in the Treatment of Large Nasal Skin Mass [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(5): 342-344.
[12]	CHEN Jia,BIAN Weiwei,ZHUANG Leilan,HUANG Ying. The Effects of Different Feeding Methods on the Postoperative Rehabilitation after the Resection of Cervical Scar and Skin Grafting [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(4): 260-262.
[13]	LI Fen,CHENG Chen,LI Hua,ZAN Tao. Experimental Study on Improving Survival Rate of Prefabricated Skin Flap with Hypoxic Preconditioning Agent [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(3): 142-151.
[14]	MIN Peiru,SU Weijie,XU Heng,SONG Wenchao,ZHANG Yixin. Application of Modified Skin-Stretching Technique in the Treatment of Skin Defect in Lower Limbs [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(3): 155-158.
[15]	YANG Lin,BIAN Weiwei. Pain Level and Influencing Factors in Patients Undergoi Skin Soft Tissue Expansion [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(3): 194-197.

Skin γδT-Cell Functions in Epithelium Integrity and Wound Healing

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments