Abstract: Objective To observe the effectiveness and safety of conscious sedation with dexmedetomidine and sufentanil in liposuction surgery. Methods From January 2018 to June 2018, 40 female patients (ASA Ⅰ-Ⅱ) scheduled for liposuction surgery were included. The patients were infused l μg/kg intravenously within 10minutes as loading dose followed by a continuous infusion of dexmedetomidine 0.4μg/Kg·h-1. Sufentanil 0.2 μg/Kg were administrated intravenously before infusion of tumescent solution. Sufentanil 5-10 μg was given increased because of movement caused by surgical stimulation. The drug infusion was discontinued at 5 to 10 min before the end of the surgical procedure. Hemodynamics, respiratory changes, Ramsay Sedation Score (RSS) were observed and registered at the time point of before sedation, 15, 30, 60 min after sedation and the end of the surgery. The complications (anoxemia, apnea, bradycardia, etc), anesthesia duration and drug consumption were recorded. Results All patients were satisfied with the conscious sedation (Ramsay sedation level: 2~4). The induction of sedation produced a significant decrease in HR (P<0.05). The SBP, DBP were significantly decreased 15 minutes after sedation, compared with pre-sedation (P<0.05). There were no significant differences in SBP and DBP at other time points after sedation compared with pre-sedation (P>0.05). There were no significant changes in RR and SpO2after sedation (P>0.05). Hypoxia and bradycardia were observed in 2 patients respectively. No serious adverse reactions occurred. The anesthesia duration and consumption of dexmedetomidine, sufentanil were (168±58) min, (126±36) μg, (15±5) μg respectively. Conclusion Conscious sedation with dexmedetomidine and sufentanil is an effective and safety anesthetic technique in patients for liposuction surgery.

Key words: Conscious sedation, Dexmedetomidine, Sufentanil, Liposuction