Abstract: Objective To evaluate clinical effect of free anterolateral thigh adipofascial flap transplantation and autologous fatgraft to repair facial soft tissue defection in severe progressive facial hemiatrophy.Methods From September 2013 to December 2015,16 patients with progressive facial hemiatrophy were selected according to enter criterion.The patientswere divided into two groups according to different surgicalmethods,autologous fat graftgroup(Group A,n=8)and free anterolateral thigh adipofascial flap group(Group B,n=8).The facial three-dimensional data were acquired via 3-D scanner preoperatively.Using Mimics 17.0 and Geomagic studio 12.0 software,facial 3-Dmodel of patientwas reconstructed, facial symmetry was analyzed,the volume of facial tissue defect was calculated and the reconstruction scope of facial soft tissue was designed.All the patients were operated and clinical indexeswere analysed after 6 months.Results The facial symmetry and soft tissue defect in Group A and Group B 6 months post-operation were both significantly improved compared with pre-operation(P＜0.05),while therewas no statistical significance between group A and group B(P＞0.05).The patients′clinical indexes:total operation time,postoperative hospital stay in Group B were greater than in Group A,times of hospitalization of Group B surpassed Group A with statistical significance(P＜0.05).Facial 3-D deviation analysis:there was no statistical significance between group A and group B(P＞0.05).Satisfaction score:patients postoperative satisfaction in Group A was better than in Group B(P＜0.05).The third person and surgeon satisfaction:no significant difference betweenthe two groups(P＞0.05).Conclusion The clinical effectof autologous fatgraft in repairing facial soft tissue defectof severe PFHA patients is non-inferior to free anterolateral thigh adipofascial flap transplantation with good clinical effects and high satisfactory,and isworthy of clinical application.

Key words: Three-dimensional digital technology, Progressive facial hemiatrophy, Autologous fat graft, Anterolateral thigh adipofascial flap transplantation