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23 July 2020, Volume 13 Issue 3 Previous Issue    Next Issue

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The Significance of Epithelium-to-Mesenchymal Transition in Keloid Treatment ZHANG Mingzi,WANG Xiaojun 2017, 13 (3):  121-122.  DOI: 10.3969/j.issn.1673-0364.2017.03.001 Abstract ( 452 )   Keloid scar is a fibrogenesis tumor-like disease featured by invasion to the surrounding skin. Epithelium-to-mesenchymal transition (EMT) is a process which leads to the loss of epithelial cell polarity and cell-cell adhesion. Through the process of EMT, epithelial cells acquire migratory and invasive behavior and are thus able to transform into mesenchymal cells. EMT has a high clinical significance towards keloid treatment. Related Articles | Metrics

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Construction of Penis-Shaped Cartilage Using Tissue Engineering and 3D Printing Technologies YUA N Zhaoyuan,NING Jin, CHEN Jie, XIA Huitang, TA O Ran, ZHOU Guangdong, XIA O Kaiyan, CA O Yilin 2017, 13 (3):  123-142.  DOI: 10.3969/j.issn.1673-0364.2017.03.002 Abstract ( 716 )   Objective To explore the feasibility of constructing a penis-shaped cartilage using tissue engineering and 3D printing technologies. Methods A composite scaffold composed of PCL/HA and PGA/PLA were prepared for the reconstruction of penis-shaped cartilage by 3D printing. The penis-shaped PCL/HA scaffold prepared by 3D printing was beset between two separate PGA/PLA scaffolds that have a penis-shaped appearance. Articular chondrocytes were obtained from one-day-old roasters and then proliferated in order to meet the need of seeding sufficient cell into grafts. Cell-seeded constructs were cultivated in cartilage-inducing media for 4 weeks and then implanted under the dorsum skin of athymic nude mice. After 8 weeks' cultivation in vivo, constructs were harvested and grossly observed. Then the specimens were sagittally dissected to observe the interface between the regenerated cartilage and the porous PCL/HA scaffold and histology of engineered cartilage was examined in vivo. Results Penis-shaped models made of PCL/HA were printed into an exact penis shape and then composite scaffolds were assembled into a verisimilar penis. In the process of reconstruction, the initial shape of cell-seeded constructs were generally maintained. The surface of the specimens was smooth and continuous and no vascularization was observed. In cross section, the PCL/HA core were completely surrounded by the homogeneous neocartilage and the two phase interlocked well with each other. Conclusion It is feasible to construct a penis-shaped cartilage with the PCL/HA core surrounded by the homogeneous neocartilage by using tissue engineering and 3D printing technologies. Related Articles | Metrics

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Preparation and Characterization of Fe3O4 Magnetic Nanopaticles Loaded PLGA Microspheres CHEN Hong,XU Jumei,ZHAO Shicheng,CEN Lian 2017, 13 (3):  127-130.  DOI: 10.3969/j.issn.1673-0364.2017.03.003 Abstract ( 616 )   Objective To prepare Fe3O4 magnetic nanopaticles loaded poly(lactic-co-glycolic acid) (PLGA) microspheres using microfluidics, and to characterize this microspheres for future possible applications as targeted drug delivery and MRI tracking. Methods PLGA-Fe3O4 microspheres were prepared by three-phase microfluidic devices. Morphology of microspheres and distribution of Fe3O4 magnetic nanopaticles inside PLGA microspheres were analyzed. Results The PLGA-Fe3O4 microspheres prepared by microfluidic method had uniform particle size distribution and excellent dispersibility. The results of elemental analysis confirmed the presence of Fe, and the results of TEM observation showed that Fe3O4 magnetic nanopaticles were well dispersed inside the microspheres without agglomeration. Conclusion The feasibility of Fe3O4 magnetic nanopaticles loaded PLGA microspheres prepared by microfluidic method is demonstrated. The current study thus provides possibility of using PLGA microspheres for targeted drug delivery and MRI tracking. Related Articles | Metrics

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The Feasibility of Using Cell-Hydrogel to Integrate PCL Inner Support with Cell-Sheet XU Yawen,, HE A ijuan,,LIU Yu,, ZHOU Guangdong, CAO Yilin 2017, 13 (3):  131-159.  DOI: 10.3969/j.issn.1673-0364.2017.03.004 Abstract ( 396 )   Objective To explore the feasibility of using sandwich model, PCL as an inner support encapsulated by chondrocyte sheet, to create tissue-engineered (TE) cartilage; To explore the feasibility of integrating PCL with chondrocyte sheet by injecting the mixture of Pluronic F-127 hydrogel and chondrocytes. Methods The isolated auricular chondrocytes of passage 1 were seeded in six-well plate at a high density. Chondrocyte sheet formed after 4 weeks in vitro. PCL inner support encapsulated by chondrocyte sheet was set up as non-treated control group (NC group). Sandwich model injected with Pluronic F-127 hydrogel was set up as control group (PC group). Sandwich model injected with the mixture of Pluronic F-127 hydrogel and chondrocytes was set up as the experiment group (Exp group). The above constructs were implanted subcutaneously into the same nude mice (n=8). The samples were harvested 12 weeks after implantation for the evaluation of cartilage formation. Results After in vitro high cell-density culture, chondrocyte sheet formed into cartilaginous tissue. Histologically, sheet showed specific cartilage characters including cartilage lacunae and expressed GAG and collagen Ⅱ. After in vivo culture, sheet from the "sandwich" structure formed more mature cartilaginous tissue with smooth surface and flexible texture. The results of wet weight, thickness and volume from every group were significantly different. However, there was no significant difference for Young's modulus. Histologically, an abundance of cartilage-like tissue was found between PCL inner support and chondrocyte sheet in Exp group, strongly expressing GAG. Although sheet developed into mature cartilage tissue in the NC and PC group, none of cartilaginous tissue was found between the PCL inner support and chondrocyte sheet. Conclusion PCL inner support encapsulated by chondrocyte sheet could construct TE cartilage with high mechanical strength. The approach of injection with the mixture of Pluronic F-127 hydrogel and chondrocytes could realize the cartilaginous integration of PCL inner support and chondrocyte sheet. Related Articles | Metrics

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Impact of Anterior Maxillary and Mandibular Subapical Osteotomy on Hard Tissue in the Treatment of Bimaxillary Protrusion XIE Fang,XU Jiajie,LU Jianjian,ZHANG Chao,YANG Liya,LI Shuyuan,TENG Li 2017, 13 (3):  136-138.  DOI: 10.3969/j.issn.1673-0364.2017.03.005 Abstract ( 564 )   Objective To explore the impact on hard tissue after preoperative modeling and bimaxillary anterior subapical osteotomy for the treatment of bimaxillary protrusion. Methods The subjects included 20 patients with bimaxillary protrusion who underwent anterior subapical osteotomy of both the maxilla and mandible, and simultaneous genioplasty, from September 2003 to October 2014. Based on model surgical design and an occlusal guide plate, new hard tissue relationships were established for the patients. In addition, the pre- and postoperative cephalometric radiographs were systematically analyzed. Results All the surgical incisions healed by first intention with no infection or osteonecrosis. Significant differences were observed in the pre- and postoperative values of the hard tissue parameters, except for SGn-FH and Co-MP. The most obviously significant differences were seen in Id-Pog-Go (P<0.001). Postoperative follow-up lasted for 12-36 months. All patients eventually achieved normal jaw relationships, tooth arch forms and Spee curves. No evident irregularities of teeth arrangement or abnormal occlusal relationships were observed. All patients were satisfied with their postoperative facial appearance, except for one patient who underwent repeat surgery because of relapse. Conclusion With the use model surgical, orthognathic surgery, a simple and time-saving technique, can be used to correct bimaxillary protrusion with satisfactory postoperative hard tissue relationship and facial esthetic appearance, and minimal postoperative complications. Related Articles | Metrics

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The Application of Sural Neuro-Veno-Fasciocutaneous Flap in Repairing Skin Soft Tissue Defect of Ankle HOU Junjie,YANG Xin,MA Yongguang 2017, 13 (3):  139-142.  DOI: 10.3969/j.issn.1673-0364.2017.03.006 Abstract ( 381 )   Objective To investigate the application of sural neuro-veno-fasciocutaneous flap graft for repairing skin soft tissue defect of ankle. Methods From May 2008 to October 2012, 12 patients with ankle skin soft tissue defect were treated with sural neuro-veno-fasciocutaneous flap graft. Each patient's defect state, flap size, repairing effect, appearance change after the surgery, cicatricial state of the donor area, the need to graft for the secondary wound area were all reviewed. Results The ankle skin soft tissue defects in all patients were well-repaired. The outcome appearance was satisfactory, and the incision cicatrix of the donor area was not obvious. Conclusion Posterior shank area is the ideal flap donor for ankle skin soft tissue defect. Sural neuro-veno-fasciocutaneous flap could be grafted for repairing most ankle skin soft tissue defects. If the flap is not that wide, the incision of the donor area could be directly sutured, otherwise, the donor area should be repaired by free skin graft. The protection of vascular pedicle is the key to the success of the surgery. Related Articles | Metrics

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The Split-Thickness Skin Graft from Scalp in Wound Repair CHEN Deguang,YUAN Siming,XU Yuan,WANG Min 2017, 13 (3):  143-145.  DOI: 10.3969/j.issn.1673-0364.2017.03.007 Abstract ( 497 )   Objective To explore the clinical effects of the split-thickness skin graft from scalp in wound repair. Methods From January 2006 to January 2016, 27 patients received wound repair by the split-thickness skin graft from scalp. All of the wounds were located in the extremities and trunk. The size of the wounds ranged from 5 cm×9 cm to 17 cm× 21 cm. The thickness of skin graft ranged from 0.30 mm to 0.4 mm. Results Most of the skin grafts survived very well. The skin graft started to contract 1 to 3 months after transplantation, and became flat again 6 months to 1 year after transplantation with good appearance. The donor site in scalp healed in 10 to 14 days, and the hair growth was normal without scar. Conclusion Split-thickness skin graft from scalp is a good choice for the wound repair, which avoids the permanent injury on donor site, and is worthy of clinic application. Related Articles | Metrics

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Medial Epicanthoplasty Using "Epicanthal Fold Resection" Technique WANG Shujie,LI Xin,LIU Di,MA Jiguang 2017, 13 (3):  146-148.  DOI: 10.3969/j.issn.1673-0364.2017.03.008 Abstract ( 608 )   Objective To investigate a modified epicanthoplasty with simple design and inconspicuous scarring. Methods The modified epicanthoplasty was performed on 52 patients from March 2012 to Dec 2015. The procedure involves resection of redundant skin fold, manipulation of the malpositioned orbicularis oculi muscle, and exposure of the real medial canthus. Results The follow-up period ranged from 3 to 36 months. Most patients were satisfied with the results and none com-plained about visible scarring, because the only incisions were hidden in supratarsal and subciliary incisions. The epicanthal fold was effectively removed and the aesthetic eye contour was achieved. No patients experienced relapse of the epicanthal fold. Conclusion The modified epicanthoplasty corrects the epicanthal folds effectively. The technique is simple with incon-spicuous scarring. Related Articles | Metrics

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Efficacy of Non-Ablative 1540 nm Erbium-Glass Fractional Laser on Facial Post-Acne Lesions SHI Yu,ZHANG Wei 2017, 13 (3):  149-152.  DOI: 10.3969/j.issn.1673-0364.2017.03.009 Abstract ( 1120 )   Objective To evaluate the clinical efficacy and safety of non-ablative 1540 nm erbium-glass fractional laser on treating facial post-acne lesions, including atrophic scars, enlarged pores, post-acne erythema and post-inflammatory hyperpigmentation (PIH). Methods A non-ablative 1540 nm erbium-glass fractional laser was used to treat 28 patients. All patients were treated for 3-9 times with an interval of 4-week. The efficacy was assessed by A quartile grading scale, VISIA complexion analysis system and CK skin property 1 month after treatment. Results The efficacy rate of non-ablative 1540 nm erbium-glass fractional laser was 14.29% for post-acne scars, 25% for enlarged pores, 34.76% for post-acne erythema and 18.18% for PIH. Compared to pre-therapy, there was significant difference in pores, erythema and purple mass, and there was positive correlation between efficacy and treatment frequencies (P0.05). No severe adverse effect was observed. Conclusion Non-ablative 1540 nm erbium-glass fractional laser was safe and effective in treating post-acne skin lesions, especially for post-acne erythema and enlarged pores. Related Articles | Metrics

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Application of Domestic LCP with MIPPO Technique in the Treatment of Distal Femoral Fractures QIAN Jun 2017, 13 (3):  153-156.  DOI: 10.3969/j.issn.1673-0364.2017.03.010 Abstract ( 507 )   Objective To evaluate the efficacy of percutaneous plate fixation with LCP (locking compression plate) in the treatment of distal femoral fractures. Methods From January 2011 to November 2015, 18 cases of distal femoral fractures were treated with LCP transdermal plate technique. The fractures of intra-articular were only reset under the incision of the joint, and some of them needed to be fixed with the tension for anatomical reduction of the articular surface. The femoral supracondylar fracture was treated with MIPPO (minimally invasive plate percutaneous osteosynthesis) technique and fixed with the plate. Results All cases were followed up for 10~21 (15.5±5.2) months. Fractures were healed at an average time of (14.5±2.2) weeks, and the average load-bearing time was (18.5±3.2) weeks. All the incision were healed by first intention and fracture reduction was satisfied. No postoperative infection, internal fixation fracture, nonunion, deep vein thrombosis, limb shortening, knee varus and other complications were observed. The knee function was graded according to the Neer score: excellent in 13 cases, good in 5 cases, excellent and good rate was 100%. The knee join movement degrees: A3 fracture was 124 °~135 ° (130 ° ±6 ° ), C2 fracture was 85 °~135 ° (111 ° ±25 ° ), C3 fracture was 84 ° . Conclusion Percutaneous implantation of plate technique combined with domestic LCP is a safe and effective method for the treatment of distal femoral fractures. It can meet the clinical needs of primary hospital. Related Articles | Metrics

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Clinical Application of MRI in the Diagnosis of ACL and PCL after Knee Joint Injury TAN Yanzhao,TIAN Ke 2017, 13 (3):  157-159.  DOI: 10.3969/j.issn.1673-0364.2017.03.011 Abstract ( 436 )   Objective To explore the clinical application of MRI in the diagnosis of ACL and PCL after knee joint injury. Methods From January 2015 to December 2016, 65 cases with cruciate ligament injury of knee joint were randomly divided into observation group (n=33) and control group (n=32). Patients in control group were performed CT scanning, while patients in observation group received MRI scanning. The application effects of the two groups were analyzed and compared. Results There was no significant difference of the data between MRI and anatomical method on cruciate ligament (P>0.05), while there was significant difference of the data between MRI and CT (P<0.05), the MRI data was closer to the result. The cruciate ligament diagnostic coincidence rate of MRI was significantly higher than CT examination, and the difference was statistically significant (P<0.05). Conclusion MRI measurement value can reflect the reality of the knee cruciate ligament anatomy. The diagnosis coincidence rate of MRI is superior to CT examination. MRI is the first choice for non-invasive examination in the diagnosis of knee ligament injury. Related Articles | Metrics

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Study on the Construction of a Core Competency Evaluation System for Plastic and Reconstructive Surgery Specialized Ward Nurse YANG Jiafei,BIAN Weiwei,RUAN Hong,WANG Huifen,TU Yihua 2017, 13 (3):  160-168.  DOI: 10.3969/j.issn.1673-0364.2017.03.012 Abstract ( 450 )   Objective To construct a core competency evaluation system for plastic surgery specialized ward nurse. Methods The research team constructed the basic framework and questionnaire of the core competence evaluation system for plastic surgery specialized ward nurse through literature review and group discussion. Two rounds of expert consultation by questionnaires were conducted among 22 plastic surgeons, plastic surgery specialized ward nurses and nursing administra-tors in the hospital. The results of questionnaire were analyzed with computation methods of analytic hierarchy process (AHP) weight vector. Results The coefficient of determination, coefficient of familiarity and coefficient of authority was 0.923, 0.800 and 0.861, respectively. The core competency framework for plastic surgery specialized ward nurse consisted of 5 first-level indicators, 10 second-level indicators and 60 third-level indicators. The coordination coefficients for primary, secondary and tertiary indexes were 0.312, 0.148, and 0.091 respectively. Conclusion The core competency evaluation system for plastic surgery specialized ward nurse is reliable and valid, which can provide objective and quantitative standards for the employment, training and evaluation of plastic surgery specialized ward nurse. Related Articles | Metrics

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The Reason Analysis and Nursing Strategy for Poor Compliance in Hand Protection after Childhood Hand Surgery BIAN Weiwei,YANG Jiafei,WANG Hairong,LU Wei 2017, 13 (3):  165-168.  DOI: 10.3969/j.issn.1673-0364.2017.03.013 Abstract ( 446 )   Objective To explore the reason for poor compliance in hand protection after childhood hand surgery, and to propose the corresponding nursing strategy. Methods The retrospective analysis was made on the 220 children who received hand surgery from January 2016 to November 2016. The reasons for poor compliance in hand protection after childhood hand surgery were analyzed. Results The common reasons for poor compliance in hand protection post-operation of the 220 children were child patient factor, disease factor, parent factor and nursing factor. Conclusion The factors affecting the compliance in hand protection after childhood hand surgery are multiple. Regarding these factors, a positive and effective strategy should be adopted to improve the compliance in hand protection. Related Articles | Metrics

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Research Progress on the Molecular Genetics of Carpenter Syndrome BAI Shanshan 2017, 13 (3):  169-171.  DOI: 10.3969/j.issn.1673-0364.2017.03.014 Abstract ( 557 )   Carpenter syndrome, also called acrocephalo-polysyndactyly type Ⅱ, is an autosomal recessive dominant inherited disease with craniosynostosis, characterized by a combination of craniosynostosis, polysyndactyly, obesity, and other congenital malformations. CS will result in some complications including mental retardation, intracranial hypertension. To date, the majority of CS is caused by mutations in the RAB23 gene, which encodes a small GTPase of the Rab superfamily. Rab acts as an essential negative regulator of the Sonic hedgehog signaling pathway. The mutation of RAB23 in CS result in the structure and function of the protein, which probably through perturbation of signaling by hedgehog. However, the pathogenesis is not exactly clear. Some of the CS is caused by mutations in multiple EGF-like-domains (MEGF8). Related Articles | Metrics

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Research Progress of Long Noncoding RNAs in Craniomaxillofacial Development and Deformities MENG Xiaohui 2017, 13 (3):  172-174.  DOI: 10.3969/j.issn.1673-0364.2017.03.015 Abstract ( 414 )   Congenital craniomaxillofacial deformities are common human growth and development defects. A long non-coding RNA (lncRNA) is an RNA longer than 200 nucleotides that are not predicted to be translated to a functional protein product. Recently, an increasing number of studies have shown that lncRNA have a critical role in processes of craniomaxillofacial development. In this paper, the research progress of long non-coding RNAs in craniomaxillofacial development and deformities was reviewed. Related Articles | Metrics

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Application of Hyaluronidase in the Treatment of Hyaluronic Acid Injection Induced Complications CHEN Chuhsin,JIANG Cheng'an 2017, 13 (3):  175-177.  DOI: 10.3969/j.issn.1673-0364.2017.03.016 Abstract ( 431 )   As injection of hyaluronic acid has become increasingly popular, more complications, especially intravascular embolisms, have been reported in the recent years. Hyaluronidase, as specific hydrolase, have been proposed to treat such horrific adverse events. To further understand the nature and application of this enzyme, the biochemistries, clinical applications, especially in the treatment of hyaluronic acid induced complications, and adverse reactions were reviewed. Related Articles | Metrics

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Image Examination of Adult Acquired Flatfoot Deformity ZHAO Duowei 2017, 13 (3):  178-180.  DOI: 10.3969/j.issn.1673-0364.2017.03.017 Abstract ( 548 )   Adult acquired flatfoot deformity, causing by posterior tibial tendon dysfunction or insufficiency, mainly expresses midfoot abduction and hindfoot valgus as well as medial longitudinal arch collapse, and usually relates to progressive posterior tibial tendon weakening. There are many kinds of treatment methods, the purpose of the treatment is rebuilding arches with accurate forefoot and hindfoot alignment and maintain the flexibility of the foot and ankle as much as possible. In clinical, the people's understanding for adult acquired flatfoot is not sufficient, its diagnosis is mainly based on symptoms, medical history and image examination. Symptoms mainly expresses change of foot shape and later pain. Imaging examination, besides weight bearing lateral and oblique X-ray of foot, hindfoot axis X-ray, by measuring distance between the tibia axis and calcaneal axis, can be used to provide evidence for the selection of treatment. Related Articles | Metrics