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Progress in the Treatment of Hypertrophic Scars and Keloids MA Qianyu,WU Xiaoli Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 1-5.   DOI: 10.3969/j.issn.1673-0364.2020.01.001 Abstract （719）      PDF（pc） （736KB）（945）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Evaluation of facial injection filling materials for medical aesthetics ZHAO Chenyu, LI Chongchong, SUN Xue, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 517-.   Abstract （170）      PDF（pc） （874KB）（824）       Knowledge map    Save With economic development and technological progress, the demand for medical aesthetics has increased sig nificantly, and medical biomaterials are widely used. It is necessary to further improve the evaluation of their effectiveness and safety. At present, the evaluation of its physicochemical properties and biology is adopted in China. However, the clinical effec tiveness is a multi-faceted evaluation without unified criteria. Most of the evaluation mainly adopts objective indicators for quan titative analysis, while subjective feelings are secondary criteria. In this paper, the main facial fillers and the evaluation methods of their physicochemical properties were reviewed. Related Articles | Metrics | Comments（0）

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An Improved Rat Tail Animal Model of Hypertrophic Scar XU Xiangwen,KUANG Yimin,HUANG Xin,GAO Yashan,LI Haizhou,GU Shuchen,ZAN Tao Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 22-26.   DOI: 10.3969/j.issn.1673-0364.2020.01.005 Abstract （531）      PDF（pc） （5820KB）（807）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Related Complications in Orthognathic Surgery of Cleft Lip and Palate LU Ye,YIN Ningbei,SONG Tao Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 67-69.   DOI: 10.3969/j.issn.1673-0364.2020.01.018 Abstract （434）      PDF（pc） （697KB）（623）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Journal of Tissue Engineering and Reconstructive Surgery    2021, 17 (1): 61-.   Abstract （101）      PDF（pc） （4619KB）（611）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Journal of Tissue Engineering and Reconstructive Surgery    2021, 17 (6): 1-.   Abstract （267）      PDF（pc） （2707KB）（609）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Application of Acellular Dermal Matrix in Tissue Engineering and Regenerative Medicine HUANG Cheng,LUO Xusong Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 65-66.   DOI: 10.3969/j.issn.1673-0364.2020.01.017 Abstract （602）      PDF（pc） （659KB）（598）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Case Report:Crouzon Syndrome WANG Jing,YAN Qing,HE Junping,QIU Dezhi,WANG Gang Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 62-64.   DOI: 10.3969/j.issn.1673-0364.2020.01.016 Abstract （961）      PDF（pc） （3230KB）（591）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Bone Compatibility on Different Porosity of PEEK Printed by Addictive Manufacturing of Fused Deposition Modeling inVitro Wong KaIoi,ZHONG Yehong,YU Zheyuan,WEI Min Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 11-15.   DOI: 10.3969/j.issn.1673-0364.2020.01.003 Abstract （517）      PDF（pc） （5207KB）（502）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Research progress of three dimensional bio-printing technology for formation of vascular network in bone tissue ZHAI Chuanxing, WANG Zhimeng, WANG Guodong, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 298-.   Abstract （87）      PDF（pc） （913KB）（471）       Knowledge map    Save Vascularization of bone grafts is one of the major challenges facing bone tissue engineering (BTE). The ultimate goal of the construction of vascularized BTE is to provide a bone environment rich in functional vascular networks to achieve efficient bone integration and accelerate the functional recovery after implantation. In this paper, the research progress of 3D bio-printing in the formation of vascular network in bone tissue was reviewed, the formation mechanism of vascular network and the characteristics of 3D bio-printing technology were elaborated, the current vascularization strategies in BTE were summarized, and its development prospects were prospected. Related Articles | Metrics | Comments（0）

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Research Progress of the Treatment for the Lower Palpebral Bags with Tear Trough Deformity Zhen SONG, Qinghua YANG Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (3): 253-256.   DOI: 10.3969/j.issn.1673-0364.2020.03.020 Abstract （355）   HTML （39）    PDF（pc） （706KB）（466）       Knowledge map    Save The lower palpebral bags with tear trough deformity has different degrees of influence on the facial appearance and mental health of the patient. The lower eyelid blepharoplasty has been developed in the last century, and the concept and method of blepharoplasty for the lower palpebral bags with tear trough deformity have been continuously developed. In addition to surgical treatment, other treatments such as laser treatment, autologous fat transplantation, hyaluronic acid and other substances injections have their own advantages and characteristics, and have achieved good result. In this paper, the progress of the treatment for the lower palpebral bags with tear trough deformity was reviewed. Reference | Related Articles | Metrics | Comments（0）

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Overview of sensitive skin and treatment progress of aesthetic medicine LU Nan, WU Min, SONG Jiao, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 323-.   Abstract （124）      PDF（pc） （708KB）（465）       Knowledge map    Save 敏感性皮肤 ；　机制 ；　诊断 ；　治疗 ；　光电治疗 Related Articles | Metrics | Comments（0）

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Progress of Diagnosis and Treatment of Verrucous Venous Malformation Lili QIAN, Yajing QIU, Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (3): 210-213.   DOI: 10.3969/j.issn.1673-0364.2020.03.009 Abstract （954）   HTML （251）    PDF（pc） （766KB）（453）       Knowledge map    Save Verrucous venous malformation, formerly known as verrucous hemangioma, is a rare congenital vascular abnormality. It usually appears at birth or in early childhood. It enlarges with body growth and does not regress spontaneously. The early lesions are red in color, with clear boundaries. But in time they become increasingly hyperkeratotic and verrucous. It is generally accepted that surgical excision is the first choice of treatment. The incomplete excision would lead to recurrence of the lesion from the deeper components. Cryosurgery, electrocautery, laser therapy or sclerotherapy can be used to combine with surgical resection, to prevent recurrence or delay the development of lesions. In this paper, the diagnosis and treatment of verrucous venous malformation were reviewed, in order to guide the clinical diagnosis and treatment of verrucous venous malformation. Reference | Related Articles | Metrics | Comments（0）

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The incidence and risk factors of breast cancer-related lymphedema ZHANG Yingying, LI Hua, GUAN Jiaqin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 242-.   Abstract （191）      PDF（pc） （1127KB）（445）       Knowledge map    Save Objective　To explore the incidence rate, severity and risk factors of breast cancer-related lymphedema (BCRL) among breast cancer survivors. Methods　Data collected from 128 patients underwent breast cancer operation during September 1 to December 31, 2019. All the patients were female, aging (49.0±6.8) years (29-81 years). The Norman questionnaire and arm circumference measurement were used to evaluate the BCRL status and treatment status of breast cancer patients from subjective and objective perspectives at 6, 12, 24 and 36 months after surgery separately. The influence of the correlation factors on BRCL occurrence was analyzed by Logistic analysis. Results　BRCL incidences were 9.4%, 25%, 23.4% and 23.4% at 6, 12, 24, 36 months according to arm circumference measurement, while 12.5%, 26.6%, 25.0% and 25.0% by Norman questionnaire. Among the 128 patients, 30 were diagnosed with BCRL after breast cancer surgery, among which the incidence of stage Ⅰ lymphedema, stage Ⅱ lymphedema and stage Ⅲ lymphedema were 15.6%, 6.3% and 1.6%, respectively. Age, body mass index (BMI)  radiotherapy, the number of positive lymph nodes and surgery method showed differences between the the BCRL group and control group. Both CDT or LVA showed improvement for the BCRL patients. Conclusion　BCRL is a common complication for breast cancer patients after surgery. It can be fairly diagnosed in the first year after surgery without the increasing incidence of BCRL over time throughout 3 years. BMI, radiotherapy were found to be independent risk factors in the development of BCRL in this study. Related Articles | Metrics | Comments（0）

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Sclerotherapy Using Polidocanol Injectable Foam Combined with Pinyangmycin in the Treatment of Venous Malformation in Tongue of Preschoolers Liang WANG, Changhua WU, Dan SONG, Jing LI, Jie ZHOU, Xin ZHANG, Lei GUO Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (3): 182-185.   DOI: 10.3969/j.issn.1673-0364.2020.03.002 Abstract （621）   HTML （532）    PDF（pc） （816KB）（442）       Knowledge map    Save Objective To evaluate the clinical efficacy and safety of sclerotherapy using polidocanol injectable foam combined with pinyangmycin in the treatment of venous malformation in tongue of preschoolers. Methods From January 2017 to December 2018, 26 preschoolers with venous malformation in tongue treated with sclerotherapy were retrospectively analyzed. Intraoperatively, the tongue lesions were punctured from multiple angles, and after the blood was recovered, contrast agent was injected for DSA angiography, and polidocanol injectable foam or pingyangmycin was injected under DSA fluoroscopy. The general information, clinical manifestations, imaging data, therapeutic effect and complications were all recorded. Results A total of 72 sclerosing treatments were performed in 26 patients, with an average of 2.77 sclerosing treatments per patient (1-4 sclerosing treatments per patient). The clinical symptoms of all the children were relieved to different degrees, among which 4 cases were cured, 20 cases were basically relieved, and 2 cases were effective, with an overall effective rate of 100%. Short-term complications included mild swelling (23 cases) and fever (4 cases). No serious complications was observed in the 26 cases. Conclusion Sclerotherapy using polidocanol injectable foam combined with pinyangmycin is an effective and safe method with few side effect for the treatment of venous malformations in tongue of preschoolers, and is worthy of clinical promotion. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Analysis of mutation type and clinical significance of congenital melanocytic nevi ZHAO Yifei, ZOU Yun, CHEN Hui, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 258-.   Abstract （147）      PDF（pc） （843KB）（417）       Knowledge map    Save Objective To explore the molecular characteristics of giant congenital melanocytic nevi (GCMN) and their clinical significance. Methods The samples of patients diagnosed with GCMN were subjected whole-exome sequencing and bio-information analysis to clarify the pathogenic genes and distribution patterns. Results In 50 samples (25 pairs of tissues and blood) from 25 patients, 21 patients had somatic mutations, including NRAS gene (19 cases) and BRAF gene (1 case). New mutations were detected in 2 patients’ lesions and blood, and the mutant genes were MET gene and IDH1 gene. In addition, no causative mutation was detected in 4 patients. There was no statistic difference between GCMN genotype and phenotype. Conclusion NRAS somatic mutation is the most common mutation in GCMN, and BRAF gene has also been detected. Potential new mutated IDH1 and MET genes were also found. Related Articles | Metrics | Comments（0）

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Review on the feasibility of poly lactic acid as GBR barrier membrane LI Lulu, SUN Zhen, LI Na, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 189-.   Abstract （116）      PDF（pc） （837KB）（396）       Knowledge map    Save Barrier membrane is the key to the success of guided bone regeneration (GBR). The ideal barrier membrane ma terial should have good biocompatibility, mechanical properties, biodegradability and osteogenic guidance. At present, the Bio Gide biofilm is more mature in clinical application, but it is expensive and the use cost is high. Polylactic acid is a kind of material, which is simple to make, has good biocompatibility, degradability and mechanical property, and is expected to be used as a GBR barrier membrane. In this paper, the properties of polylactic acid and its feasibility as GBR barrier membrane were reviewed. Related Articles | Metrics | Comments（0）

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Research progress of tissue engineering ligament and scaffold materials ZHONG Rui, GAO Jingyu, YAN Chengyuan, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 308-.   Abstract （113）      PDF（pc） （927KB）（394）       Knowledge map    Save 　The reconstruction scheme of the existing artificial ligament products has been relatively mature in clinical ap plication. In order to prevent the occurrence of postoperative complications such as difficult tendon-bone healing, expansion of the bone tunnel, synovial inflammatory reaction, infection, and external fixation loosening after ligament reconstruction, tendon tissue construction using tissue engineering technology has become a possible development direction in the future. In this paper, the progress of the construction of tissue-engineered tendon and its scaffold materials was reviewed, the urgent problems to be solved and the future development direction were discussed. Related Articles | Metrics | Comments（0）

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Analysis of the mechanism of fibroblast involvement in scarless healing of oral mucosa based on single cell transcriptome sequencing XUANYUAN Xinyang, XU Jiacheng, WANG Mengting, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 115-.   Abstract （192）      PDF（pc） （3654KB）（391）       Knowledge map    Save Objective　To explore the heterogeneity of human normal oral mucosa and skin fibroblasts and the mechanism of oral mucosal fibroblasts in promoting scarless wound healing. Methods　Single-cell transcriptome sequencing data were obtained from the GEO database for 13 cases of oral mucosa and 8 cases of skin. The 64,633 cells were subjected to quality control, dimen sionality, clustering and cell annotation. Fibroblasts were extracted and annotated for subsets definition, differential gene enrichment and intercellular interactions analysis. Results　Fibroblasts can be divided into 5 subsets: inflammatory, adipose, mesenchymal, contractile, and Wnt-inhibited. The proportion of inflammatory fibroblasts was significantly upregulated in the oral mucosa and was associated with immune cell recruitment. CXCL13, EEF1A1 and B2M genes were highly expressed in oral mucosa fibro blasts. Gene ontology (GO) functional analysis showed that scar healing-related pathways such as immune response and pro-in flammatory pathways were activated in oral fibroblasts. Cellular interaction analysis revealed that the interaction between fibro blast subsets was significantly changed, the information flow of oral mucosal COLLAGEN signaling pathway was upregulated, and the score of collagen degradation genes including MMP1 and MMP10 were also increased (P<0.05). Conclusion　Fibroblasts in normal skin and oral mucosa differ significantly in their subpopulation and function. The stronger inflammatory characteristics and collagen metabolism of oral mucosal fibroblasts may drive the scarless wound healing. Related Articles | Metrics | Comments（0）

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Study on Sub-chronic Systemic Toxicity of 3D Printed Orthopedic Titanium Alloy WANG Han,ZHAO Danmei,XU Jianxia,LIAN Huan,QU Mingyue,HE Muye,WANG Chunren Journal of Tissue Engineering and Reconstructive Surgery    2020, 16 (1): 6-10.   DOI: 10.3969/j.issn.1673-0364.2020.01.002 Abstract （414）      PDF（pc） （673KB）（383）       Knowledge map    Save Related Articles | Metrics | Comments（0）