On the background of THAAD (Terminal High Altitude Area Defence) missile defence campaign, the defence capability and trajectory simulation of THAAD missile are investigated. Firstly, the THAAD missile’s operational process, the tactical performance, configuration parameters and thrust parameters are presented. The aerodynamic coefficients of the missile are acquired by the Missile DATCOM software. Then, the defence trajectory of a THAAD missile is designed, and the predicted impact point is estimated according to the motion characteristics of the incoming missile. According the predicted impact point, the launch data, flight program angle and launch time of the interceptor missile are calculated. Finally, THAAD interception trajectory against a medium-range ballistic missile is simulated by taking the THAAD deployed in South Korea as an example.