成人原发性横纹肌肉瘤的临床、病理及影像学特征分析

doi:10.16150/j.1671-2870.2017.03.014

诊断学理论与实践 ›› 2017, Vol. 16 ›› Issue (03): 301-305.doi: 10.16150/j.1671-2870.2017.03.014

成人原发性横纹肌肉瘤的临床、病理及影像学特征分析

唐文¹, 任刚¹, 蔡嵘², 贺文广¹, 倪婧¹, 陈健¹

1.上海交通大学医学院附属新华医院放射科,上海 200092;
2.上海交通大学医学院附属瑞金医院放疗科,上海 200025

收稿日期:2017-02-21 出版日期:2017-06-25 发布日期:2017-06-25
通讯作者: 蔡嵘 E-mail: cairong619@aliyun.com; 任刚 E-mail: rengang527@163.com
基金资助:
上海交通大学医学院科研基金(09XJ21013); 上海市卫生局科研基金(2010029,2010057); 上海市科委科研基金(124119a0300); 上海市教委科研基金(12Y2034)

Primary rhabdomyosarcoma in adults: clinicopathological characteristics, CT and MRI findings

TANG Wen¹, REN Gang¹, CAI Rong², HE Wenguang¹, NI Jing¹, CHEN Jian¹

1. Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;
2. Department of Radiotherapy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2017-02-21 Online:2017-06-25 Published:2017-06-25

摘要/Abstract

摘要： 目的: 探讨成人原发性横纹肌肉瘤(rhabdomyosarcoma,RMS)患者的临床及影像学特征。方法: 回顾性分析4例经手术病理证实的成人原发性RMS患者的临床资料和影像学表现。结果: 4例患者中,病变位于头颈部2例,位于盆腔1例,位于纵隔1例。所有患者均因相应部位肿胀或压迫症状就诊。CT显示病灶为软组织密度肿块,密度欠均匀,周围组织受压推移或侵犯;增强后病灶呈明显不均匀强化,4例患者的病灶内均可见坏死,但未见钙化成分。MRI检查T1WI图像上可见病灶呈等信号,T2WI图像上则以稍高信号为主;增强后呈不均匀持续强化。4例患者的病理组织行免疫组织化学染色,结果肌细胞生成素(Myogenin)均(+),波形蛋白(Vimentin)均(+),1例患者结蛋白Desmin(+)。结论: 成人原发性RMS罕见,其在CT及MRI图像上具有一定特征性,结合患者的临床表现进行分析,可提高诊断的准确率。

关键词: 成人原发性横纹肌肉瘤, 计算机体层摄影, 磁共振成像

Abstract: Objective: To investigate the clinicopathological characteristics, CT and MRI findings of primary rhabdomyosarcoma(RMS)in adults. Methods: Four adult patients with pathologically confirmed RMS admitted to Xinhua Hospital from 2012 to 2016 were enrolled. Results: Two patients had lesions located in head and neck, the other two in anterior chest wall and in pelvic cavity, respectively. RMS tended to be a heterogeneous soft-tissue mass with compression or invasion to surrounding tissue on non-enhanced CT image, which showed heterogeneous enhancement even with strong contrast enhancement in contrast-enhanced CT image. No fat and calcification components were found in all the 4 cases. MR imaging appearance of rhabdomyosarcoma was isointense or minimally hyperintensity in relative to muscle on T1-weighted images and hyperintensity on T2-weighted images. Conclusions: Adult primary rhabdomyosarcoma is rare, which has certain characteristic findings on CT and MRI image. Combined findings on imaging and clinical manifestations, the accuracy of diagnosis could be improved.

Key words: Adult primary rhabdomyosarcoma, Computer tomography, Magnetic resonance imaging

中图分类号:

R738.7

唐文, 任刚, 蔡嵘, 贺文广, 倪婧, 陈健. 成人原发性横纹肌肉瘤的临床、病理及影像学特征分析[J]. 诊断学理论与实践, 2017, 16(03): 301-305.

TANG Wen, REN Gang, CAI Rong, HE Wenguang, NI Jing, CHEN Jian. Primary rhabdomyosarcoma in adults: clinicopathological characteristics, CT and MRI findings[J]. Journal of Diagnostics Concepts & Practice, 2017, 16(03): 301-305.

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成人原发性横纹肌肉瘤的临床、病理及影像学特征分析

Primary rhabdomyosarcoma in adults: clinicopathological characteristics, CT and MRI findings

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