诊断学理论与实践

诊断学理论与实践 ›› 2019, Vol. 18 ›› Issue (03): 286-290.doi: 10.16150/j.1671-2870.2019.03.008

• 论著 • 上一篇    下一篇

474例中枢性性早熟女童不同年龄段垂体MRI影像学异常比例分析

朱晓雷a, 陈璐b, 陆文丽b(), 刘燕a, 严福华a, 王伟b, 董治亚b   

  1. a.上海交通大学医学院附属瑞金医院 放射科,上海 200025
    b.上海交通大学医学院附属瑞金医院 儿内科,上海 200025
  • 收稿日期:2019-05-20 出版日期:2019-06-25 发布日期:2019-06-25
  • 通讯作者: 陆文丽 E-mail:lwl11146@rjh.com.cn
  • 基金资助:
    上海市科委医学引导项目(14411958600)

Radiological findings on pituitary MRI in central precocious puberty

ZHU Xiaoleia, CHEN Lub, LU Wenlib(), LIU Yana, YAN Fuhuaa, WANG Weib, DONG Zhiyab   

  1. a. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    b. Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2019-05-20 Online:2019-06-25 Published:2019-06-25
  • Contact: LU Wenli E-mail:lwl11146@rjh.com.cn

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摘要：

目的： 本研究通过分析不同年龄段中枢性性早熟（central precocious puberty,CPP）女童的垂体MRI特征,结合其临床及生化指标,比较不同年龄段垂体MRI影像学异常比例,探讨6岁及以上的CPP女童进行垂体MRI检查的必要性。方法： 收集2013年~2016年本院474例确诊的CPP女童,平均年龄为（7.90±1.58）岁,将其按年龄分为≤6岁组和>6岁组2组。所有患儿都有完整的垂体MRI平扫或平扫+增强影像检查资料。由2名影像科主治医生分别观察所有患儿的影像资料,并记录阳性结果和阴性结果,最后对2组间的垂体MRI特征进行对比。结果： 474例CPP女童中有52例（10.9%）存在异常垂体MRI表现。≤6岁患儿组中有2例垂体MRI表现异常,这2例影像学诊断均为错构瘤。>6岁患儿组有50例垂体MRI表现异常,影像学诊断为生殖细胞瘤1例、透明隔囊肿1例、松果体囊肿2例、Rathke囊肿19例、微腺瘤27例。2组间比较,垂体MRI检查阳性率差异无统计学意义（ χ2=0.514 4, P>0.05）。结论： 在≤6岁及6~8岁的CPP女童中均有一定比例的患儿经垂体MRI检出异常改变,6~8岁女童MRI异常表现以微腺瘤较多见,故建议对所有的CPP女童进行垂体MRI检查。

关键词: 中枢性性早熟, 磁共振成像, 垂体

Abstract:

Objective: To investigatethe features of pituitary MRI in different age groups of girls with central precocious puberty (CPP), and to compare the clinical and biochemical parameters and the proportion of abnormal pituitary MRI imaging to provide a clinical basis for exploring the necessity of pituitary MRI in CPP girls. Methods: A total of 474 cases of CPP girls diagnosed in our department from 2013 to 2016 were collected. The average age was (7.90±1.58) years old. Patients were divided into two groups according to age: less than or equal to 6 years old group and greater than 6 years old group. All patients had a complete pituitary MRI plain scan, or plain scan + enhanced MRI. Two radiologists observed the imaging of all these children, and recorded positive and negative findings; and the two groups were compared. Results: Of the 474 CPP girls, 52 (10.9%) had abnormal pituitary MRI findings. There were 2 cases of pituitary MRI abnormalities in the group of children less than or equal to 6 years old, and the 2 cases were diagnosed as hamartoma. There were 50 cases of pituitary MRI abnormalities in the group older than 6 years old. The imaging diagnosis was 1 case of germ cell tumor, 1 case of clear septum cyst, 2 cases of pineal cyst, 19 cases of Rathke cyst, and 27 cases of microadenoma. Among the 11 children who were less than or equal to 6 years old, 2 were positive, and 50 of the 463 children older than 6 years were positive. The chi-square test was not statistically significant (χ2=0.514 4, P>0.05). Conclusions: In children with CPP, there is a certain proportion of abnormal pituitary MRI findings in children before 6 years and after 6 years of age. It is recommended that pituitary MRI should be performed in all the children with CPP.

Key words: Central precocious puberty, Magnetic resonance imaging (MRI), Pituitary

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