二维超声在产前胎儿胸腺发育评估中的应用

doi:10.16150/j.1671-2870.2021.05.010

诊断学理论与实践 ›› 2021, Vol. 20 ›› Issue (05): 471-474.doi: 10.16150/j.1671-2870.2021.05.010

二维超声在产前胎儿胸腺发育评估中的应用

杨田¹, 吉翔², 牛建梅¹, 孔晓晓¹, 吕明丽¹()

1.上海交通大学医学院附属国际和平妇幼保健院超声科,上海市胚胎源性疾病重点实验室上海市临床重点专科建设项目-“强主体”妇产科,上海 200030
2.上海交通大学生物医学工程学院,上海 200240

收稿日期:2021-05-25 出版日期:2021-10-25 发布日期:2022-06-28
通讯作者: 吕明丽 E-mail:fengyunyuer2003@163.com
基金资助:
上海交通大学“医工交叉研究基金”(YG2017 QN40);上海市医苑新星(沪卫人事〔2020〕087号)

Application of 2D-ultrasonography in prenatal assessment of fetal thymus development

YANG Tian¹, JI Xiang², NIU Jianmei¹, KONG Xiaoxiao¹, LV Mingli¹()

1. The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai 200030, China
2. Shanghai Jiao Tong University School of Biomedical Engineering, Shanghai 200240, China

Received:2021-05-25 Online:2021-10-25 Published:2022-06-28
Contact: LV Mingli E-mail:fengyunyuer2003@163.com

摘要/Abstract

摘要：

目的：探讨超声检查在评估胎儿胸腺发育中的价值,同时观察母体服用优甲乐是否会影响胎儿胸腺发育。 方法：收集2018年1月至2021年1月来我院超声科进行产前超声检查的健康孕妇311名（18~40周）（健康组）,每名孕妇检查1次,另收集同期因甲状腺功能减退（甲减）而服用优甲乐治疗的孕妇31例（孕28周14例,孕34周17例）（优甲乐组）。采用二维超声观察2组胎儿胸腺的形态、回声及大小,并测量胎儿胸腺前后径、横径、周长及面积。分析健康组各超声参数与胎龄间的相关性;比较2组胎儿胸腺相关参数的差异,探讨母体服用优甲乐对胎儿胸腺发育的影响。 结果：健康组二维超声检查胎儿胸腺的各参数（前后径、横径、周长及面积）随胎龄的增加而增加,成线性相关,并得出线性回归方程;优甲乐组与同期健康组间的胎儿胸腺超声参数差异无统计学意义。 结论：二维超声检查可在产前评估胎儿胸腺发育情况;母体服用优甲乐对胎儿胸腺发育无明显影响。

关键词: 超声, 胎儿胸腺, 甲状腺功能减退

Abstract:

Objective: To investigate the value of prenatal ultrasound measurement of thymus size and to determine whether maternal administration of euthyrox affects fetal thymus development. Methods: A total of 311 healthy pregnant women(18-40 weeks of gestation)(healthy Group) were enrolled,and prenatal ultrasound examination were performed once in each pregnancy in the department of ultrasound of the hospital from January 2018 to January 2021.In addition, 31 pregnant women (14 cases at 28 weeks and 17 cases at 34 weeks) who took euthyrox(euthyrox Group) for hypothyroidism were selected. The morphology, echo and size of fetal thymus were observed and the anteroposterior diameter, transverse diameter, circumference and area of fetal thymus were measured by 2D-ultrasound;The correlation between ultrasonic parameters and gestational age in healthy group and was analyzed. The differences in thymus related parameters between the euthyrox Group and health Group were compared to determine if maternal administration of euthyrox may affect fetal thymus development. Results: The parameters of fetal thymus (the anteroposterior diameter, transverse diameter, circumference and area)in the healthy group were linearly correlated with gestational age. There was no significant difference in parameters of fetal thymus between the euthyrox group and the healthy group during the same period. Conclusions: 2D-ultrasound may serve as an effective approach to assess prenatal thymus development,and maternal administration of euthyrox had no effect on fetal thymus development.

Key words: Ultrasound, Fetal thymus, Hypothyroidism

中图分类号:

R445.1

杨田, 吉翔, 牛建梅, 孔晓晓, 吕明丽. 二维超声在产前胎儿胸腺发育评估中的应用[J]. 诊断学理论与实践, 2021, 20(05): 471-474.

YANG Tian, JI Xiang, NIU Jianmei, KONG Xiaoxiao, LV Mingli. Application of 2D-ultrasonography in prenatal assessment of fetal thymus development[J]. Journal of Diagnostics Concepts & Practice, 2021, 20(05): 471-474.

图/表 5

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参考文献 13

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孕周	例数（n）	APD（cm）	MTD（cm）	TC（cm）	MTA（cm²）
18	5	0.64±0.10	1.67±0.63	4.94±0.32	1.06±0.51
19	5	0.67±0.11	1.85±0.16	5.21±0.37	1.30±0.17
20	5	0.69±0.12	1.94±0.27	5.71±0.63	1.31±0.75
21	5	0.71±0.17	1.96±0.31	5.73±0.33	1.33±0.13
22	22	0.74±0.13	2.05±0.23	6.03±0.29	1.61±0.31
23	10	0.75±0.12	2.17±0.19	6.39±0.79	1.78±0.45
24	15	0.85±0.15	2.19±0.26	6.43±0.65	1.93±0.37
25	13	1.05±0.46	2.33±0.51	7.22±0.59	2.30±0.44
26	7	1.06±0.33	2.49±0.44	7.56±0.55	2.77±0.65
27	8	1.07±0.17	2.63±0.39	7.93±1.20	2.85±0.58
28	26	1.16±0.25	2.84±0.19	8.58±0.81	3.39±0.63
29	27	1.19±0.11	3.00±0.27	8.90±0.94	3.63±0.76
30	17	1.22±0.13	3.03±0.28	8.92±0.29	4.12±0.56
31	15	1.27±0.29	3.11±0.25	9.23±1.10	4.23±1.09
32	29	1.37±0.23	3.30±0.30	9.71±0.99	4.31±0.69
33	12	1.50±0.22	3.51±0.33	10.33±0.87	4.90±0.95
34	31	1.51±0.36	3.53±0.32	10.38±1.04	4.99±1.32
35	14	1.53±0.29	3.59±0.63	10.46±1.32	5.15±1.00
36	4	1.57±0.39	3.64±0.58	10.54±0.64	5.44±1.49
37	14	1.61±0.16	3.81±0.37	11.09±1.04	5.55±0.62
38	6	1.63±0.12	3.85±0.46	11.30±1.02	5.82±0.42
39	4	1.64±0.31	3.95±0.28	11.49±0.92	6.01±0.89
40	3	1.77±0.21	4.14±0.38	12.13±1.35	6.37±0.98

指标	APD	MTD	TC	MTA
孕周	0.867	0.909	0.866	0.828
P值	<0.001	<0.001	<0.001	<0.001

参数	线性回归方程	P值
APD	APD=-0.387+0.054×孕周	<0.01
MTD	MTD=-0.395+0.113×孕周	<0.01
TC	TC=-1.002+0.329×孕周	<0.01
MTA	MTA=-3.899+0.258×孕周	<0.01

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二维超声在产前胎儿胸腺发育评估中的应用

Application of 2D-ultrasonography in prenatal assessment of fetal thymus development

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