Expression of T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain on T cells in patients with recurrent spontaneous abortion

doi:10.16150/j.1671-2870.2017.03.008

Abstract

Abstract: Objective: To investigate the expression of TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain) on peripheral T cells in patients with recurrent spontaneous abortion(RSA). Methods: Proportion of TIGIT⁺ T cells and the expression of IFN-γ and IL-10 of TIGIT⁺ T cells were detected in 21 normal pregnant women and 23 RSA patients. Results: Compared with normal pregnant women, the proportion of TIGIT⁺ T cells were detected in RSA patients was significantly higher [(41.52±7.17)% vs (36.09±4.03)%)] (P<0.05), and the IL-10 expression of TIGIT⁺ T cells in RSA group were lower than normal pregnant group [(11.68±5.90)% vs (16.33±6.65)% ](P<0.05). The expression of IFN-γ in the two groups had no significant difference. Conclusions: The abnormal expression of TIGIT may be involved in the regulation of maternal-fetal immune tolerance and is related with the occurrence of RSA.

Key words: Recurrent spontaneous abortion, T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain, Mechanism

CLC Number:

R541.7

CHEN Ying, LI Cui, YING Chunmei. Expression of T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain on T cells in patients with recurrent spontaneous abortion[J]. Journal of Diagnostics Concepts & Practice, 2017, 16(03): 273-276.

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