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25 June 2017, Volume 16 Issue 03 Previous Issue    Next Issue

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Correlation of sperm morphology and acrosome index with fertility rate of in vitro fertilization and embryo transfer HUANG Wenqiang, FAN Yuping, HU Ye, YANG Yang, JIANG Ningdong, HUANG Meiyuan, PAN Jiaping, TENG Xiaoming 2017, 16 (03):  270-272.  DOI: 10.16150/j.1671-2870.2017.03.007 Abstract ( 358 )   PDF (397KB) ( 212 )   Objectives: To investigate the influence of morphological parameters of sperm on fertility rate of in vitro fertilization and embryo transfer (IVF-ET) and discuss the clinical significance of sperm morphological parameters. Methods: Data form 824 couples underwent IVF-ET in our IVF center during April, 2016 to September, 2016 were analyzed retrospectively. Inclusion criteria were female infertility due to female tubal factors and the method of controlled ovulation induction was short-term long protocol. Number of retrieved oocyte was 6 to 15. Failure of oocyte retrieval, rescue ICSI and short co-incubation of gametes were excluded. Male inclusion criteria were total number of progressive motile sperm more than 5 million in two CASA tests, and patients with genetic and infectious factors were excluded. Altogether 136 couples were enrolled. Sperm morphology test was performed according to WHO 5th edition manual and acrosome index was calculated by image software. Logistic regression analysis was performed for statistical analysis. Results: The mean age of enrolled male patients was (34.12±4.30) years (ranging from 27-46 years) and female patients was( 32.32±4.14 ) years (ranging from 25-43 years). Their mean infertility time was(2.77±1.34) years (ranging from 1-8 years). The rate of sperm head abnormality was in significant negative correlation with fertility rate(P=0.035), and acrosome index had a significant positive correlation with fertility rate (P=0.046), whereas other CASA and morphological parameters had no correlation with fertility rate. Conclusions: The rate of sperm head abnormality and acrosome index may adversely affect the fertility rate of IVF. Therefore, the morphological tests should not only focus on normal morphology rate, but also should pay attention to the classification of various sperm anomalies for obtaining a better prediction of IVF outcome. References | Related Articles | Metrics

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Expression of T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain on T cells in patients with recurrent spontaneous abortion CHEN Ying, LI Cui, YING Chunmei 2017, 16 (03):  273-276.  DOI: 10.16150/j.1671-2870.2017.03.008 Abstract ( 437 )   PDF (469KB) ( 80 )   Objective: To investigate the expression of TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain) on peripheral T cells in patients with recurrent spontaneous abortion(RSA). Methods: Proportion of TIGIT+ T cells and the expression of IFN-γ and IL-10 of TIGIT+ T cells were detected in 21 normal pregnant women and 23 RSA patients. Results: Compared with normal pregnant women, the proportion of TIGIT+ T cells were detected in RSA patients was significantly higher [(41.52±7.17)% vs (36.09±4.03)%)] (P<0.05), and the IL-10 expression of TIGIT+ T cells in RSA group were lower than normal pregnant group [(11.68±5.90)% vs (16.33±6.65)% ](P<0.05). The expression of IFN-γ in the two groups had no significant difference. Conclusions: The abnormal expression of TIGIT may be involved in the regulation of maternal-fetal immune tolerance and is related with the occurrence of RSA. References | Related Articles | Metrics

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Comparison of abnormal karyotypes of early spontaneous aborted fetus in patients with different ways of pregnancy ZHOU Jing, ZHANG Shuo, XU Jianzhong, YIN Min, LEI Caixia, WU Junping, ZHANG Yueping 2017, 16 (03):  277-281.  DOI: 10.16150/j.1671-2870.2017.03.009 Abstract ( 346 )   PDF (553KB) ( 130 )   Objective: To investigate whether assisted reproductive technology increases the risk of fetal chromosomal abnormalities. Methods: According to the way of pregnancy, 2 318 early abortion cases were divided into three groups, IVF (in vitro fertilization) group (310 cases), ICSI (intracytoplasmic sperm injection) group (86 cases), and NC(natural conception)group (1 922 cases). Frequency of abnormal karyotypes in the three groups were compared, and the correlation between age of pregnant woman and rate of aneuploidy as well as the performance of various methods for detecting abnormal karyotype were analyzed. Results: A total of 1 420 cases of chromosomal abnormality were detected in 2 318 aborted fetus, with an abnormal rate of 61.26% (1 420/2 318). In all abnormal karyotypes, aneuploidies accounted for 1 040 cases (73.24%, 1 040/1 420), which involved all chromosomes except chromosome 1. The frequency of trisomy 16 was the highest, followed by trisomy 22 and X monomer. Differences in the total chromosome abnormality rate between IVF group, ICSI group and NC group were not significant (57.74%, 55.81%, 62.02% respectively, P=0.207), but the incidence rate of triploid in ICSI group was significantly lower than those in NC group and IVF group (0 vs. 7.23% and 7.42%, P=0.035). The aneuploidy rate in pregnant women aged ≥35 years was significantly higher than that in younger women (<35 years old) (60.25% vs. 40.07%, P<0.01). Compared with other detectiontion rates of unbalanced structural chromosome abnormalities, triploid, and micro repeats and/deletions by SNP-array were different from NGS and cell karyotype analysis (62.94% vs. 53.13% and 59.92%, respectively, P=0.035), and SNP-array also could detecte UPD(uniparentaldisomy) and LOH(loss of heterozygosity). Karyotype analysis had the highest detection rate for tetraploid. Conclusions: The fetal chromosome abnormality is one of the most important causes of spontaneous abortion.and IVF as well as ICSIdo not increase the total incidence rate of fetal chromosomal abnormalities, but ICSI might increase the risk of fetal sex chromosome aneuploidy. Thepregnant women's age could be related to the increase of fetal aneuploidy. Molecular detection technologies, such as SNP-array and NGS are expected to replace karyotype analysis method as a first-line method for chromosome detection. References | Related Articles | Metrics

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Karyotype analysis of 5 067 infertile patients FAN Weimin, CHENG Meiyu, SI Chenchen, ZHANG Aijun 2017, 16 (03):  282-286.  DOI: 10.16150/j.1671-2870.2017.03.010 Abstract ( 428 )   PDF (563KB) ( 831 )   Objective: To detect and analyze the chromosome karyotype in infertile patients. Methods: Lymphocyte culture and harvesting was performed according to the standard method, karyotypes were analyzed by G-banding in all cases and C-banding in some cases in addition. Results: One hundred and seven cases were detected having abnormal karyotypes from all 5 067 infertility cases and the detection rate was 2.11%, 207 cases were detected having polymorphism and the positive rate was 4.09%, both were higher than those among normal population. The incidence of chromosomal abnormalities was similar between males and females, however, the abnormal sex chromosome number had a higher positive rates in men than in women, while there was more low level mixed chimerism in women (P<0.05). In addition, there were higher detection rates of chromosome secondary constriction and chromosome 9 inversion. The negative impact of polymorphism on reproduction should be paid attention. Conclusions: Chromosomal abnormalities or polymorphism is one of the important causes for infertility and history of adverse pregnancy. References | Related Articles | Metrics

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Evaluation of foot microcirculation by contrast-enhanced ultrasound in elderly male type 2 DM and IGT patients JI Ri, ZHOU Chun, ZHAN Weiwei, YANG Zhifang, GUO Wenjia 2017, 16 (03):  287-291.  DOI: 10.16150/j.1671-2870.2017.03.011 Abstract ( 411 )   PDF (862KB) ( 125 )   Objective: To evaluate the foot microcirculation in type 2 diabetes mellitus and impaired glucose tolerance patients using contrast-enhanced ultrasound. Methods: Contrast-enhanced ultrasound (CEUS) was performed for examining the blood flow of right foot great toe (TIC) in 56 patients with type 2 diabetes mellitus but without diabetic foot (DM group), 15 patients with impaired glucose tolerance (IGT group) and 12 male control subjects(control group). DM group was divided into two groups according to the course of DM: DM(A) group with course <10 years and DM(B) group with course≥10 years. All the subjects were elderly male patients. Perfusion characteristics of CEUS and parameters of TIC were analyzed. Results: Compared with control group, CEUS image showed lower microvascular density and pale in appearance in IGT, DM and DM(B) groups. Peak intensity (PI) and area under time-intensity curve (AUC) in IGT, DM(A) and DM(B) groups were significantly reduced (P<0.05); PI and AUC of DM(B) group were lower than those of IGT and DM(A) group (P<0.05); and no significant differences in PI and AUC were found between IGT and DM(A) group (P>0.05). The arrival times (AT) and time to peak (TTP) tended to be increased with the extension of DM course, but the difference was not statistically significant (P>0.05). Conclusions: Contrast-enhanced ultrasound can detect the change in foot microcirculation of DM and IGT patients before diabetic foot occurres. References | Related Articles | Metrics

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Evaluation of ventricular systolic function and left ventricular synchrony in patients with dilated cardiomyopathy using single beat real-time three-dimensional echocardiography CHEN Yefen, SHI Zhongwei 2017, 16 (03):  292-296.  DOI: 10.16150/j.1671-2870.2017.03.012 Abstract ( 325 )   PDF (627KB) ( 140 )   Objective: To assess the ventricular systolic function and left ventricular synchrony in patients with dila-ted cardiomyopathy using single beat real-time three-dimensional echocardiography (sRT-3DE). Methods: Seventeen patients with dilated cardiomyopathy (DCM group) and seventeen healthy subjects (control group, age and sex matched) undergone sRT-3DE examination were enrolled in this study.Full-volume imaging was performed and the data were analyzed by left ventricular analysis software and right ventricular analysis software. Results: ① The parameters of left ventricular volume: In DCM group, the end systolic volume and diastolic volume were larger and the ejection fraction was lower than that of the control group (P<0.01). ②The parameters of left ventricular geometry: In DCM group, the end systolic sphericity index and end diastolic sphericity index were larger than that of the control group (P<0.01). ③ The systolic synchrony parameters were significantly larger in DCM group (P<0.01). ④ The parameters of right ventricular volume: In DCM group, the systolic volume and diastolic volume were larger and the ejection fraction was lower than that of the control group (P<0.01). Conclusions: sRT-3DE can accurately and rapidly assess the ventricular systolic function and left ventricular synchrony in patients with dilated cardiomyopathy. Thus, it's a useful and feasible routine quantification technique in patients with DCM in clinical practice. References | Related Articles | Metrics

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A study of cases with ABO typing discrepancy and the strategy of blood transfusion WANG Yuqing, CAI Xiaohong, GONG Songsong, WANG Xuefeng, ZOU Wei 2017, 16 (03):  297-300.  DOI: 10.16150/j.1671-2870.2017.03.013 Abstract ( 890 )   PDF (450KB) ( 397 )   Objective: To analyze the cause of ABO typing discrepancy and to explore the strategy of blood transfusion. Methods: ABO blood group was identified by serological method, and the cases with ABO typing discrepancy were confirmed by molecular biological method. Results: Seventy-four cases of ABO typing discrepancy were detected in 84 487 cases, the discrepancy rate was 0.09%. Removing repeated cases, there were 67 cases: red blood cell antigen weakened 43 cases, blood group antibody weakened 9 cases, both antigen and antibody weakened 2 cases, subtypes 12 cases, others 1 case. In 36 hospitalized patients of ABO typing discrepancy, 25 cases received blood transfusion, and 22 were patients with hematological disorder. Excluding subtype cases, analysis of the effect of blood transfusion between 15 cases of same ABO genotype RBC and 5 cases of O blood type washed RBC showed no significant difference (P=0.225>0.05). Conclusions: The largest number of ABO typing discrepancy are patients with hematological disorders. Compatible ABO or same gene type RBC should be used in clinical blood transfusion. Both serological and molecular biological methods should be taken into account. References | Related Articles | Metrics

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Primary rhabdomyosarcoma in adults: clinicopathological characteristics, CT and MRI findings TANG Wen, REN Gang, CAI Rong, HE Wenguang, NI Jing, CHEN Jian 2017, 16 (03):  301-305.  DOI: 10.16150/j.1671-2870.2017.03.014 Abstract ( 474 )   PDF (854KB) ( 479 )   Objective: To investigate the clinicopathological characteristics, CT and MRI findings of primary rhabdomyosarcoma(RMS)in adults. Methods: Four adult patients with pathologically confirmed RMS admitted to Xinhua Hospital from 2012 to 2016 were enrolled. Results: Two patients had lesions located in head and neck, the other two in anterior chest wall and in pelvic cavity, respectively. RMS tended to be a heterogeneous soft-tissue mass with compression or invasion to surrounding tissue on non-enhanced CT image, which showed heterogeneous enhancement even with strong contrast enhancement in contrast-enhanced CT image. No fat and calcification components were found in all the 4 cases. MR imaging appearance of rhabdomyosarcoma was isointense or minimally hyperintensity in relative to muscle on T1-weighted images and hyperintensity on T2-weighted images. Conclusions: Adult primary rhabdomyosarcoma is rare, which has certain characteristic findings on CT and MRI image. Combined findings on imaging and clinical manifestations, the accuracy of diagnosis could be improved. References | Related Articles | Metrics

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Analysis of performance of microfluid chip ELFA and IBT for detecting allergen specific IgE ZHAO Jie, ZHAO lingxu, HU Xiaobo 2017, 16 (03):  306-312.  DOI: 10.16150/j.1671-2870.2017.03.015 Abstract ( 709 )   PDF (612KB) ( 229 )   Objective: To compare the performance of BioIC Allergen specific IgE Detection Kit (micro-fluid chip enzyme-linked fluoroimmunoassay, ELFA) and EUROLINE Atopy China (immunoblotting test, IBT) for detecting allergen-specific IgE. Methods: The stability and dilution of these two methods were compared by using mixed human plasma with strong positivity for multi-sIgE and horse plasma, and the positive levels of common allergens were also compared. Results: The CV% of ELFA was obviously lower than that of IBT in six kinds of allergens including mite mix, crab, shrimp, peanut, egg white and dog dander(T=6.20, P<0.01), while was slight higher in cat dander,cockroach and milk(T=2.43, P>0.05). Both IBT and ELFA showed a positive correlation of testing result with concentration dilution. There was a high consistency of positive grading for mite mix and cockroach, while a weak consistency for peanuts and other five kinds of allergens. Conclusions: There are some differences between ELFA and IBT, but both could reflect the concentration of sIgE. Compared with IBT, ELFA has a higher stability and sensitivity, covering more allergens, less testing time and sample volume. ELFA could be used in allergen-specific IgE testing in clinical laboratory. References | Related Articles | Metrics

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Anaplastic large cell lymphoma: a clinicopathological study and review of literature YI Lin, XIAO Li, CHEN Yan, YIN Yulei 2017, 16 (03):  313-319.  DOI: 10.16150/j.1671-2870.2017.03.016 Abstract ( 501 )   PDF (1998KB) ( 190 )   Objective: To investigate the clinicopathological feature of anaplastic large cell lymphoma (ALCL). Methods: A total of 12 cases of ALCL were enrolled and the clinicohistopathological characteristics, results of immunophenotyping, fluorescence in situ hybridization (FISH) were analyzed. The relevant literatures were reviewed. Results: Patients were 6 males, 6 females, aged from 22 to 81 years, with an average of 47 years. B symptoms occurred in 9 cases. Extranodal lesions or also with lymph node lesions simultaneously were involved in 5 cases. Microscopically, ALCL was composed of pleomorphic large tumor cells predominantly, horseshoe-shaped nuclei cells were found in all cases, and adhesive growth pattern was seen in some cases. Small cell variant was seen in 1 case, and sarcomatoid features in 2 cases; 4 cases were positive for ALK, while 8 were negative for ALK. Positive staining for CD30 was seen in all the 12 cases, while positive for CD2 in 7 cases, CD3 in 5 cases, CD5 in 3 cases, CD7 in 2 cases, both positive for CD4/CD8 in 2 cases. In addition, cytotoxicity was found in various degree in 5 cases. Separating signal was found by FISH in all the 4 cases which were positive for ALK by immunohistochemical staining. Conclusions: ALCL patients usually present with B symptoms and tend to be involved in extranodal sites. Microscopic pathology reveals pleomorphic feature and often lacking some T lymphocyte-associated antigens. Combined detection of T cell markers is important for diagnosis and differential diagnosis. References | Related Articles | Metrics

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Prediction of fetal growth restriction by uterine artery Doppler and level of PAPP-A at 11-13+6 weeks of gestation HE Biyuan, ZHOU Yuqing 2017, 16 (03):  320-323.  DOI: 10.16150/j.1671-2870.2017.03.017 Abstract ( 328 )   PDF (500KB) ( 91 )   Objective: To evaluate the predictive level for fetal growth restriction (FGR) at 11-13+6 weeks of gestation by uterine artery Doppler or/and level of PAPP-A. Methods: A prospective study was performed on 2 000 singleton pregnancies attending routine care at 11-13+6 weeks of gestation. Uterine artery Doppler ultrasound was performed and maternal serum pregnancy associated plasma protein A( PAPP-A) level was assayed. The maternal and neonatal outcome were followed up. Results: ① Among the 2 000 cases,13 pregnancies were terminated for fetal abnormalities or intrauterine fetal death before 28 weeks, 76 cases developed FGR, 426 cases were proved having other adverse pregnancy outcomes, and the remaining 1 485 cases had normal outcomes. ② Compared with normal group, the mean uterine artery pulsatility index(PI)and uterine resistance index(RI)and the presence of early diastolic notch in blood flow were higher and PAPP-A level was lower in FGR group.③ In screening FGR, the combination of uterine artery PI and PAPP-A had a sensitivity of 81.6%, and the combination of uterine artery PI, PAPP-A and the presence of early diastolic notch increased the sensitivity to 82.9%, yet the difference did not reach statistical significance. Conclusions: Uterine artery PI together with PAPP-A and presence of early diastolic notch at 11-13+6 weeks could provide sensitive prediction of the development of FGR. However, the effectiveness of presence of early diastolic notch is not as good as that of uterine artery PI or maternal serum PAPP-A level in screening FGR. References | Related Articles | Metrics

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Predictive value of epicardial adipose tissue thickness detected by ultrasonography for coronary artery disease LI Junwei, XIA Hanbing, ZHAO Hongli, LIU Shuxia 2017, 16 (03):  324-327.  DOI: 10.16150/j.1671-2870.2017.03.018 Abstract ( 555 )   PDF (466KB) ( 116 )   Objective: To explore the predictive value of epicardial adipose tissue thickness (EATT) for coronary artery disease (CAD) as a non-invasive approach for predicting CAD. Methods: A total of 134 cases with suspected CAD were enrolled,and 56 patients were diagnosed as CAD by coronary computerized tomographic angiography (CTA). EATT was measured by ultrasonography. The predictive factors were compared between the patients with CAD (CAD group, n=56) and patients without CAD (non-CAD group, n=78). Multivariate logistic regression analysis was used to screen the independent predictive factors of CAD. The receiver operating characteristic(ROC) curve was used to evaluate the diagnostic value of EATT for CAD. Results: The EATT of CAD group and non-CAD group were (6.45±1.71) mm and (4.89±1.41) mm, respectively (t=5.781, P<0.001). After adjusting the confounding factors, such as body mass index (BMI), age,hypertension, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and family history of CAD, EATT was independently associated with CAD(OR=3.753, P=0.001). The area under the ROC curve of EATT for diagnosis of CAD was 0.760(P=0.001), and when 5.55 mm was taken as the cut-off point, the specificity, sensitivity and accuracy were 71.43%, 71.80% and 71.64%, respectively. Conclusions: EATT is independently associated with CAD, it can be used as a preliminary screening test for subjects at a high risk of CAD. References | Related Articles | Metrics

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Effects of aerobic exercise on self-reported health status in rheumatoid arthritis patients: A meta-analysis YANG Jing, BAO Yang, PANG Xiaofen, NIE Zihuai, CUI Yu 2017, 16 (03):  328-332.  DOI: 10.16150/j.1671-2870.2017.03.019 Abstract ( 402 )   PDF (1243KB) ( 140 )   Objective: To assess the effects of aerobic exercise on self-reported health status in rheumatoid arthritis patients. Methods: PubMed, Cochrane Library, EMbase, CBM, VIP, Wangfang data, CNKI were screened to search randomized controlled trial (RCT) and quasi-randomized control trial involving RA patients who received aerobic exercise as treatment. All the relevant studies published in Chinese or English before July 2015 were included. The meta-analysis was conducted using Review Manager Version 5.3. Results: Seven RCTs published in English including 644 RA patients were included, of them 327 patients had aerobic exercise as treatment (intervention group), and 317 patients without aerobic exercise were served as control group. Health Assessment Questionnaire-Disability Index(HAQ-DI) score of intervention group were higher than that of control group [MD=-0.14, 95%CI(-0.23, -0.05), P=0.001], as well as fatigue score [SMD=-0.16, 95%CI(-0.31,-0.01), P=0.04]. Subgroup analysis indicated that short-term intervention (≤16 weeks) of aerobic exercise was more effective than long-term intervention (≥24 weeks) for both HAQ-DI score and fatigue score. There was no significant difference in pain score between the two groups. Conclusions: Aerobic exercise could significantly improve the body function and may have a positive effect on fatigue score in RA, but further high-quality, randomized controlled trials are needed to evaluate its long-term effect. References | Related Articles | Metrics

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Expression and significance of MTA1 in different cervical lesions GU Qing, PAN Xiaolin, ZHAO Yan 2017, 16 (03):  333-337.  DOI: 10.16150/j.1671-2870.2017.03.020 Abstract ( 284 )   PDF (755KB) ( 69 )   Objective: To investigate the expression and significance of metastasis associated gene 1(MTA1) protein in normal cervix, chronic cervicitis, cervical intraepithelial neoplasia (CIN) and cervical cancer tissues. Methods: Biopsy paraffin sections including 40 cases of cervical cancer,45 cases of CIN, 30 cases of chronic cervicitis, 20 cases of normal cervix were investigated. Expression of MTA1 protein were examined by immunohistochemistry, and results were analyzed statistically using semiquantitative method. The correlation of MTA1 expression with biological behavior of cervical cancer was explored, including pathological classification, histological grade, clinical stage and lymph node metastasis. Results: Rates of high expression of MTA1 differed between cervical cancer, CIN and normal cervix (P<0.05). There was no difference in rate of high expression of MTA1 between chronic cervicitis and normal cervix(P>0.05). There were significant di-fferences in high expression rate of MTA1 between low grade squamous intraepithelial lesion(LSIL), high grade squamous intraepithelial lesion(HSIL) and cervical cancer tissues( P<0.05). Rate of high expression of MTA1 was correlated with degree of differentiation, lymph node metastasis and clinical stage, and was not associated with pathological type. Conclusions: MTA1 expression is low in normal and chronic cervicitis issue, and is high in CIN and cervical cancer tissue. Rate of high expression of MTA1 is in close association with the differentiation degree, lymph node metastasis and clinical stage of cervical cancer. References | Related Articles | Metrics

Medical education

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Application of scenario-based training in endocrine and metabolic diseases education GU Weiqiong, SHI Juan, MEI Wenhan, ZHAO Dandan, DENG Yuying, ZHANG Tianyue, HONG Jie, ZHANG Yifei 2017, 16 (03):  338-341.  DOI: 10.16150/j.1671-2870.2017.03.021 Abstract ( 366 )   PDF (502KB) ( 204 )   Objective: The scenario-based training is a new model in endocrine and metabolic diseases education. Further discussion in discovering the potential, choosing the proper methods and finding the impact on students of this model are needed. In the present study, we evaluated the characteristics of two models: the problem-based learning (PBL) methods and "Metabolic Management Center" teaching modality in the education of endocrine and metabolic diseases. Results: For the former, we collected questionnaires in the PBL case in endocrine from 91 students in grade 3 in 8-year medical program, and for the latter, we collected questionnaires from 25 students in 8-year medical program and 15 visiting physician who have attended the "Metabolic Management Center" teaching modality. Results: For the former, the scores were between 4.48 and 4.91 (5 as the highest) for each choices involved in the assessment of both the cases and the teachers. For the latter, students scored were higher in degree of satisfaction, class atmosphere, and mastering the idea of integrated management in metabolic diseases in "Metabolic Management Center" teaching modality as compared with those in traditional ward teaching modality(P=0.042, 0.025 and 0.006, respectively). Conclusions: The scenario-based training enriched the forms and methods in endocrine and metabolic diseases education. It not only could be accepted by the medical students, but also improve the learning interest, class atmosphere, and ability in mastering the concepts in the field of endocrine and metabolism. References | Related Articles | Metrics

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An investigation and evaluation on present teaching situation of hematology JIN Shiwei, JIN Xiaomu, YU Wenyan, MI Jianqing 2017, 16 (03):  342-346.  DOI: 10.16150/j.1671-2870.2017.03.022 Abstract ( 325 )   PDF (482KB) ( 237 )   Objective: To investigate the current teaching situation of hematology, and to explore teaching methods for improving interest and satisfaction in inmedical students. Methods: A questionnaire of present teaching situation of hematology was designed, and 240 medical students who were receiving medical clinical practice teaching in Ruijin Hospital were recruited and surveyed. Master degrees in knowledge of hematology theory, teaching frequency and teaching methods were explored, as well as effect of clinical practice opportunities on learning satisfaction and interests in students. The software SPSS 23.0 was used to analyze statistics. Results: Overall 41.4% of students were interested in hematology after clinical practice, while 40.6% of students showed satisfaction in hematology. Compared with those who were taught less than twice a week, students who receive teather's guide at least twice a week were more interested in hematology. Conclusions: Since hematology is a subject quite difficult to understand, it is important to improve the way of teaching, and combine theories with clinical practice to achieve better teaching effectiveness, which may stimulate students' interest and promote independent learning in learning hematology. References | Related Articles | Metrics